The incidence of acute renal failure nearly 1/3 due to drug causes, and mostly occurred in the original disease of the elderly patients. Among them, aminoglycosides, cephalosporins antibiotics, diuretics and contrast agents are the main nephrotoxic drugs.
Acute renal failure, drug-induced up to 28.9%, 51% of patients over 60 years of age, combined with the basic disease to chronic kidney disease is the most common, accounting for about 20%. In addition, cerebrovascular disease, diabetes, high blood pressure, coronary heart disease is also a common underlying disease. In nephrotoxic drugs, antibiotics accounted for the first (48%), followed by diuretics and contrast agents.
With the development of medicine, antibiotics, imaging contrast agents are widely used in clinical, accompanied by the problem of drug-induced kidney damage has become increasingly prominent. Drug-induced renal damage in the clinical manifestations of large differences, coupled with the kidney itself has a strong compensatory capacity, so often difficult to find early, it is often delayed diagnosis and treatment, resulting in irreversible renal failure.
Generally speaking, Excessive dosage and long course of treatment are the main causes of kidney damage after treatment. Therefore, taking the above drugs, the first principle is to insist on rational use of drugs, and avoid misuse of drugs. At the same time, try to avoid the use of two or more than two kinds of nephrotoxic drugs, and adjust the dosage and course of treatment according to the state of renal function in the high-risk group.上一篇：Kidney disease signal: hematuria, proteinuria and high creat