Nephritis patients in the active treatment at the same time, are also very concerned about how to carry out their own care to relieve kidney damage. Recent scientific research experiments show that nephritis patients with low-fat diet can effectively relieve renal damage, the treatment of nephritis play a very good supporting role. Then let us understand the role of low-fat diet.
Rats were fed with 4% cholesterol and 1% sodium chitate supplemented with high fat diet to establish high fat model for experimental study. The results showed that rats fed a high-fat diet for 8 weeks that significantly increased urinary protein, increased blood lipids, especially serum total cholesterol and low-density lipoprotein cholesterol increased. This confirms that high-fat diet can cause healthy kidney damage.
Further study found that, with high fat diet, with the increase in blood lipids, urinary excretion of nitric oxide in rats increased significantly, increased nitric oxide synthase in the kidney; high fat diet in rats increased superoxide, The superoxide ion in the kidney also increases, and nitric oxide reacts with superoxide ions to produce peroxynitrite that is toxic to cells. A series of studies suggest that the possible mechanisms of high-fat diet leading to kidney damage are: nitric oxide and react with superoxide ions in the kidney to produce peroxynitrite that is toxic to kidney cells, causing cells Apoptosis. Nitric oxide increased with proteinuria, increased nitric oxide synthase expression and increased nitric oxide may lead to glomerular sclerosis and renal tubulointerstitial kidney damage through apoptosis. In the study also found that nitric oxide synthesis inhibitor can prevent glomerular mesangial cells to dissolve, prevent proteinuria and reduce the expression of glomerular transforming growth factor beta and extracellular matrix accumulation, to prevent glomerular sclerosis.
These experiments fully explain the low-fat foods can prevent glomerular sclerosis, effectively alleviate kidney damage, care and treatment of nephritis is of great help. Not only can play a role in controlling the disease, but also help the rehabilitation of nephritis.
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