The latest study shows that high-fat diet will not only increase the kidney damage in patients with kidney disease, but also lead to healthy kidney damage. Researchers were fed with high-fat diet consisting of 4% cholesterol and 1% sodium cholate, and set up a high-fat model for experimental study. The results showed that rats fed a high-fat diet for 8 weeks that significantly increased urinary protein, increased blood lipids, especially serum total cholesterol and low-density lipoprotein cholesterol increased. This confirms that high-fat diet can cause damage to healthy kidneys.
Further study found that, with high fat diet, with the increase in blood lipids, urinary excretion of nitric oxide in rats increased significantly, increased nitric oxide synthase in the kidney; high fat diet in rats increased superoxide, the superoxide ion in the kidney also increases; nitric oxide reacts with superoxide ions to produce peroxynitrite which is toxic to cells. A series of studies suggest that the possible mechanisms of high-fat diet leading to kidney damage are: nitric oxide and react with superoxide ions in the kidney to produce peroxynitrite that is toxic to kidney cells, causing cells apoptosis. Increased nitric oxide and proteinuria, increased nitric oxide synthase expression and increased nitric oxide may lead to glomerular sclerosis and tubulointerstitial renal damage through apoptosis. They also found in the study, nitric oxide synthesis inhibitors can prevent glomerular mesangial cells to dissolve, prevent proteinuria and reduce the expression of glomerular transforming growth factor beta and extracellular matrix accumulation, to prevent glomerular sclerosis.
The study emphasizes that all patients with renal impairment must be treated with lipid-lowering therapy when they develop hyperlipidemia. They should also control their diet and adjust their diet according to the causes of kidney damage. In general, patients with kidney disease should try to use a light diet, Eat less high-fat diet, which has a protective effect on delaying kidney damage.
Beijing In China