Hemolytic uremic syndrome (HUS) is mainly manifested as microvascular hemolysis, thrombocytopenia and acute renal failure syndrome. If accompanied by neurological symptoms and non-infectious fever was thrombotic thrombocytopenic purpura (TTP). So both HUS and TTP in clinical manifestations and etiology is very similar, are thrombotic microvascular disease.
The cause of hemolytic uremia is unknown yet, and may be related to infection (virus, bacteria, rickettsia), genetic and other factors (such as scleroderma, pregnancy, oral contraceptives). These factors contribute to damage to endothelial cells, destroying the negative charge of endothelial cells in physiological conditions, and the synthesis and release of endothelial cells with dilated blood vessels and inhibition of platelet aggregation of PGI2 reduction, making platelet aggregation increased; endothelial cells to start the white blood cells And plasma protein coagulation, causing micro-thrombosis, so a large number of platelets are consumed by thrombocytopenia caused by bleeding; red blood cells through the micro-thrombosis when the blood vessels lead to red blood cell damage, deformation, hemolytic anemia. Microvascular embolism occurs most often in the kidneys, leading to acute renal failure.
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