Generally speaking, anemia can occur at all stages of chronic renal failure. Some patients have no clear history of kidney disease and have never had a urine test before. Once you find yourself pale, you tend to mistake for iron deficiency anemia. In fact, it is a kidney anemia. It is a common complication of chronic renal failure. About 90% of erythropoietin in human body is produced by the kidney, which plays a key role in regulating the normal pision, development and maturation of erythrocytes.
The main causes of renal anemia are: bleeding tendency caused by platelet dysfunction; Erythrocyte destruction increased; Patients with advanced renal insufficiency had erythroid hematopoiesis inhibitors in their serum. Hyperparathyroidism can cause myelofibrosis to reduce erythrocyte formation, inhibit hematopoiesis and accelerate the destruction of erythrocytes. Erythropoietin (EPO) production is a major hormone that stimulates erythropoietin production in the kidneys, and decreases when the kidneys are extensively damaged, and in chronic renal failure. With the destruction of renal units, erythropoietin produced and secreted by the kidney decreases, leading to renal anemia.
However, erythropoietin deficiency is not the only cause of renal anemia, many other factors also participate in or promote the formation of renal anemia, such as shortened red blood cell life, iron deficiency, folic acid deficiency, malnutrition. Acute and chronic inflammation, chronic hemorrhage (loss of gastrointestinal tract, etc.), severe hyperparathyroidism, aluminum poisoning and hypothyroidism.
Renal anemia can cause a series of adverse consequences, affecting almost every organ system throughout the body. In cardiovascular aspects, it can cause cardiac enlargement, myocardial hypertrophy, and increase the occurrence of cardiovascular events (such as coronary events). Heart failure and cerebral infarction are independent predictors of congestive heart failure and death. Accelerating the progression of nephropathy and deterioration of renal function; Leading to cognitive dysfunction; Menstrual disorder, sexual dysfunction; Decreased immune function; Affect quality of life, increase death and increase hospital stay.
Therefore, it is necessary to remind patients that once they find that they have serious anemia symptoms, don't forget to examine your kidney carefully and actively cooperate with treatment with the correct attitude after the diagnosis of renal anemia.
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