Many uremic patients, even if doctors recommend dialysis treatment, every day also has more than 1000ml urine, why uremia patients have so much urine, but also need accept dialysis treatment? The main reason is that the quality of urine has changed greatly in uremic patients compared with healthy people.
Urine is the main product of kidney work. The kidneys excrete 20g urea nitrogen, 10 - 15g salt, 2G potassium, 1 - 2G uric acid and 1 - 1.5g creatinine excretion by urination every day. To make these metabolites fully dissolved, completely discharged, need daily excretion of 1000 ~ 1500ml in the urine; when water, sweating and other dehydration conditions, to conserve water and kidney as concentrated urine, this time also need at least daily excretion of 400ml in urine, in order to fully dissolve and excretion of metabolites, otherwise it may cause accumulation a variety of metabolic products, causing uremia symptoms.
Human kidney urine production in 2 stages, the first is the generation of primary glomerular filtration of urine, human urine is generated every day 150 to 180 liters; generating primary urine after renal tubular, selective absorption in the urine of the body back to the original useful substances and 99% of the water, and then generate the urine.
The elimination of metabolites and toxins in the body depends mainly on the amount of urine produced, and insufficient urine production will cause uremia symptoms. While there are patients with uremia renal tubular injury and dysfunction, generation of urine is greatly reduced, and the inability to concentrate urine; therefore the content of various metabolites in urine of uremic solute in healthy people rarely, equivalent to about 1%-5%.
Even if 1000ml urine is excreted every day, the metabolites produced by uremic patients are only equivalent to the amount of urine 10-50ml produced by healthy people, which can not meet the needs. Therefore, uremia patients need dialysis treatment, does not depend on the patient's urine volume, even if there is urine, if other inpidual needs dialysis treatment, also must begin dialysis treatment.
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