What are the important symptoms of uremia? Uremia serious damage to people's spirit and torture everyone's health, if want avoid disease, we need to correctly grasp the important symptoms of uremia, and help you find suitable treatment methods, so as to reduce the occurrence of diseases.
Important symptoms of uremia:
(1) disorder of water and sodium metabolism, mainly manifested as retention of water and sodium, or low blood volume and hyponatremia. When renal insufficiency occurs, the kidney's ability to adapt to excess sodium or excessive capacity gradually decreases. If uremia patients not limiting water, can lead to excessive volume load, different degrees of common subcutaneous edema (eyelids, lower limbs) and / or effusion (pleural and abdominal), at this time prone to high blood pressure, left ventricular dysfunction (chest tightness performance, activity intolerance and even could not lie down at night) and brain edema. On the other hand, when the patient has a large amount of urine, and over restriction of water, and also vomiting, diarrhea and other digestive symptoms, it can easily lead to dehydration. In clinical capacity overload is common, so patients in uremic intake should pay attention to proper control of water (except drinking water also includes soup, rice porridge, fruit, and other foods contain more water), avoid excessive fluid during the treatment process, to prevent the occurrence of heart failure and pulmonary edema.
(2) metabolic acidosis: chronic kidney failure at uremia period, the acidic products of human metabolism, such as phosphoric acid, sulfuric acid and other substances, because of renal excretion obstruction and retention, can occur “uremic acidosis". Mild chronic acidosis, most patients have few symptoms, such as arterial blood HCO3<15 mmol/L, can appear obvious loss of appetite, vomiting, weakness, deep breathing etc..
(3) potassium disorders: when GFR was reduced to 20-25ml/min or less, the renal excretion of potassium capacity decreased gradually, then prone to hyperkalemia; especially when excessive intake of potassium, acidosis, infection, trauma, such as gastrointestinal bleeding occurs, more prone to hyperkalemia. Severe hyperkalemia (serum potassium, >6.5mmol/L) is dangerous and requires prompt treatment (see hyperkalemia treatment). Hypokalemia can sometimes occur due to insufficient potassium intake, excessive gastrointestinal loss, and the use of potassium and diuretic agents. Hyperkalemia is the most common clinical manifestation, so patients with uremia should strictly limit the intake of foods containing potassium, and should review the blood potassium periodically.
(4) disordered metabolism of calcium and phosphorus: mainly phosphorus deficiency and calcium deficiency. Chronic renal failure renal generation 1, 25- (OH) 2D3 decreased, intestinal calcium absorption is reduced; the target organ of 1, 25- (OH) 2D3 resistant, the renal tubular reabsorption of calcium decreased, in addition, hyperphosphatemia can make higher calcium phosphate product, promote the deposition of calcium phosphate, calcium induced ectopic and hypocalcemia. Food is rich in phosphorus, blood phosphorus concentration by the absorption of phosphorus in the intestinal tract and excretion of the kidney to regulate. When the decline in glomerular filtration rate, urinary P excretion decreased when phosphorus concentration increased gradually, hyperphosphatemia further inhibited 1, 25- (OH) 2D3 synthesis, exacerbation of hypocalcemia. Parathyroid glands secrete more PTH to maintain blood calcium. Lead to Secondary hyperparathyroidism (referred to as hyperparathyroidism).
The important symptoms of uremia, you must understand, we know that the occurrence of uremia serious harm to the spirit, to reduce the damage of the disease, we must correctly grasp the important symptoms of uremia, and helping people find the targeted therapy, so as to avoid the occurrence of disease.