How to treat swelling of nephritic syndrome?

How to treat swelling of nephritic syndrome?

Nephrotic syndrome usually presents as "three high and one low", a large number of proteinuria, a high degree of edema, hyperlipidemia, hypoproteinemia. Many patients with renal syndrome in the diagnosis of the disease before no incentive to disease. In people over the age of 40, the incidence of kidney disease has reached 1%. But at present, many people misunderstand the disease. Some patients experience body edema, that is acute, did not mind, but they never imagined, once suffering from nephrotic syndrome, is a chronic disease. How to treat swelling of nephritic syndrome?

How to treat swelling of nephritic syndrome?

The occurrence and development of nephrotic syndrome is a long-term process, which is called kidney fibrosis. Proteinuria as an early manifestation of fibrosis, due to glomerular basement membrane damage, resulting in the leakage of macromolecular proteins, prone to cause hypoproteinemia, systemic edema is the cause of this. A large number of proteinuria late accumulation in the mesangial area, can cause damage to mesangial cells, resulting in a series of inflammatory reactions, mesangial cells undergo phenotypic transformation, resulting in mesangial cell proliferation, increased synthesis of extracellular matrix. In addition a large number of proteinuria can also lead to the formation of ammonia increased, thus contributing to the release of cytokines and a series of inflammatory mediators, leading to increased collagen synthesis during fibrosis and promote fibrosis.

In addition to a large number of proteinuria, persistent hyperlipidemia, hypoproteinemia may also exacerbate or promote the process of renal fibrosis. Such as persistent hyperlipidemia can lead to mesangial cell proliferation, endothelial cell damage, resulting in increased extracellular matrix. Eventually, excessive extracellular matrix deposition and aggregation will replace healthy nephrons, leading to glomerulosclerosis, tubulointerstitial fibrosis, renal vascular sclerosis, and renal failure uremia.

What about systemic edema in nephrotic syndrome?

From the timing of treatment, diet and other factors to consider. With the progress of fibrosis can not be controlled in time, the health of glomerular nephron injury gradually increased filtration function gradually decreased until the toxins can not be excreted, creatinine increased. If creatinine continues to rise up to 707 constitutes a diagnostic criteria for uremia. If you reach the above criteria, it should pay close attention to the time of treatment, but missed the timing of treatment! In the diet: the general taboo, protein should be an appropriate increase, but azotemia should be limited; edema, hypertensive children Sodium should be limited, severe edema should limit the amount of water into. If necessary, blood plasma and blood transfusion can increase serum protein, reduce edema. In case of infection, antibiotics should be given to the kidneys. Diuretic is also to be done to reduce swelling, oral hydrochlorothiazide or spironolactone, furosemide when necessary.

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