Nephrotic syndrome is a general term for four symptoms: high edema, high levels of urinary protein, hyperlipidemia, and hypoalbuminemia. Which of the four symptoms is the most serious?
First: a large number of urine protein, nephrotic syndrome, a large number of urine protein, refers to 24 hours urine protein more than 3.5 grams.
The severity of large amounts of urinary protein: Proteins continue to leak, further disrupting the filtration barrier and causing more protein to leak out.
Second: hypoproteinemia, mainly refers to the plasma albumin dropped below 30g / L. Serum albumin is a serious decline, due to a large number of urinary protein.
The severity of hypoproteinemia: albumin is too low not only easy to cause edema (colloid osmotic pressure imbalance), will also reduce the immunity, so that patients with kidney disease decline in physical fitness, more likely to trigger new infections (such as cold).
Third: hyperlipidemia, decreased plasma albumin, will lead to compensatory increase in lipoprotein, causing hyperlipidemia. The so-called hyperlipidemia, can be simply understood as blood becomes thick.
The severity of hyperlipidemia: easily lead to thrombosis, especially deep venous thrombosis, serious life-threatening.
Fourth: a high degree of edema, edema caused by nephrotic syndrome, is due to lower serum albumin colloid osmotic pressure caused by imbalance. This edema is usually symmetrical means concave edema, often spread to the whole body by both lower extremities.
The severity of edema: High edema not only affects the appearance, but also cause acute pulmonary edema and acute heart failure, serious life-threatening.
However, it should be noted that: If a large number of urinary protein and high degree of edema, there should be priority to solve the edema, because the hormone will cause sodium and water retention, swelling of patients with nephropathy.
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