Some people can not tell the difference between nephrotic syndrome and renal insufficiency. This is actually two completely different concepts. Although different, but also between them there is a certain correlation.
The core symptom of nephrotic syndrome is massive proteinuria. The kidney is like a "sieve" of human blood. It filters out the metabolic waste in the blood while retaining the essence of cells, proteins and sugars. A variety of causes of kidney disease, will glomerular filtration membrane damage, resulting in filtration ability to damage the body's proteins and other essences along with the urine leak out, this is urine protein.
Glomerular filtration membrane damage more serious, more protein leakage more. When the urinary protein is more than 3.5g / 24h quantitatively, it is said that a large amount of proteinuria; excessive loss of protein in the body hypoproteinemia; low plasma protein, colloid osmotic pressure drops, the water in the blood to the subcutaneous, abdominal and other edema In addition, since albumin and lipoprotein are produced in equal proportions, albumin is lost with the urine and the lipoprotein is left behind, so that the lipoprotein accumulates and finally forms hyperlipidemia.
Nephrotic syndrome is not an independent disease, but a group of clinical syndromes. No matter what kind of kidney disease, as long as there is a lot of proteinuria and hypoproteinemia, you can diagnose nephrotic syndrome.
Chronic renal insufficiency, and now more often called chronic renal failure. The core symptoms of chronic renal failure are elevated serum creatinine, or decreased glomerular filtration rate.
Under normal circumstances, the body's two kidneys are not all at full capacity. When part of glomerular sclerosis can not work, does not affect renal function. However, about half of glomerular sclerosis, renal function is affected, manifested as elevated serum creatinine, or glomerular filtration rate decreased, then called chronic renal failure. Do not think that high blood creatinine that the kidney is no problem; once serum creatinine increased, often means that about half of the glomeruli have been sclerosis.
Chronic renal failure is also a group of clinical syndromes. Nephrotic syndrome, or other kidney disease, is diagnosed with chronic renal failure as long as serum creatinine increases or glomerular filtration rate declines.
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