Nephrotic syndrome is not a disease, no matter what the cause of nephropathy, as long as there is a large amount of proteinuria (urine protein ≥ 3.5g / d), hypoproteinemia (plasma albumin ≤ 35g / L), hyperlipidemia and edema , Are known as nephrotic syndrome.
The cause of nephrotic syndrome:
Primary glomerulonephritis: Including membranous nephropathy, minimal change, mesangial proliferation, focal sclerosis and other types.
Secondary nephropathy: children with common allergic purpura nephropathy, the cause of adult even more: diabetes, systemic lupus erythematosus, systemic small vessel vasculitis, hepatitis B and AIDS and other viral infections, multiple myeloma, cancer, obesity, etc. Can cause nephrotic syndrome.
Primary nephrotic syndrome, adults and children of the three main puncture pathology are: minor lesions, focal segmental glomerulosclerosis, membranous nephropathy, the doctor according to different puncture pathology, will take a different treatment options.
Partial amyloidosis in patients. Nephrotic syndrome is caused by amyloidosis, which can be dispensed with if it can be diagnosed by other less invasive tests such as abdominal fat pad or rectal biopsy.
Children's nephrotic syndrome. More than 90% of children with nephrotic syndrome, usually younger than 6, are minor and can be treated directly with minimal disease. For 6-18-year-old children with nephrotic syndrome, some experts believe that the first treatment can be based on minimal changes in the treatment response and then decide whether the renal puncture.
Nephrotic syndrome consider and non-steroidal anti-inflammatory drugs, penicillamine, heavy metal poisoning related. Nephrotic syndrome caused by these factors, often slowly recovered after withdrawal, so you can not puncture, and some recovery time can be extended to several years.
Simple diabetic nephropathy. Such patients often have a history of diabetes for many years, damage the kidneys, microalbuminuria from the beginning, the development of significant proteinuria, can be treated accordingly to diabetic nephropathy.
Have been diagnosed with malignant tumors. Solid tumors can cause membranous nephropathy, hematologic malignancies such as leukemia lymphoma can cause minor lesions, if you consider malignant nephrotic syndrome, you can not puncture, usually nephropathy after tumor treatment to ease.
Slow progress in proteinuria in obese patients. Obese patients slowly increase the amount of protein to nephrotic syndrome, the pathology is usually secondary focal segmental glomerulosclerosis, can effectively reduce the urine protein by weight loss. However, in the event of a sudden onset of nephrotic syndrome in an obese patient, renal puncture is usually required.
Beijing In China