What are the causes of nephrotic syndrome with hyperlipidemia?

What are the causes of nephrotic syndrome with hyperlipidemia?

Many patients with nephrotic syndrome develop hyperlipidemia signs, and even on an empty stomach the plasma can act like lactic acid. This is the rise of various lipids in the blood, in which the neutral lipid increases the most, as well as triglyceride, cholesterol increased, and its elevation is negatively correlated with the decline in plasma albumin.

What are the causes of nephrotic syndrome with hyperlipidemia?

In most patients with nephrotic syndrome, plasma lipids increase, even when fasting, the plasma can be milky. Although many kinds of lipids in the blood can be increased, neutral lipids increase most, cholesterol and triglyceride are increased, and the degree of which is negatively correlated with the decrease of serum albumin. Early blood cholesterol >7, 15 mmol / L, can be increased to about 25 and 86 mmol / L, and the ratio of cholesterol to phospholipid increased to 1.28. Xanthoma can appear on the skin of the patient.

The mechanism of hyperlipidemia in nephrotic syndrome is not clear enough. Nephrotic syndrome patients often emit large amounts of protein in the urine to plasma protein decreased, hypoalbuminemia may be compensatory to make proteins, especially the synthesis of accelerated lipoprotein such as VLDL, VLDL and can be converted to LDL, LDL increased, may cause hyperlipidemia.

It has been found that vascular lesions such as atherosclerosis, embolism and thrombosis can occur in the presence of long-term hyperlipidemia. In patients with chronic renal insufficiency, decreased the activity of lipoprotein lipase, caused by decomposition due to increased triglyceride disorders in patients with chronic renal insufficiency of blood triglyceride levels, vascular lesions occur easily, so be careful to reduce high blood fat. But these hyperlipidemia patients are not suitable for diet treatment, so lowering blood lipids should be chosen with cholic acid combination of lipid-lowering resin and niacin.

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