In patients with nephrotic syndrome, the most important symptom is a large amount of urine protein, a large number of urinary protein loss, for the glomerulus, tubules and so on will cause damage, resulting in fibrosis of the kidney.Here is a detailed description of the risk of nephrotic syndrome associated with urinary protein (nephritic, syndrome, proteinuria), for your reference only.
Biological changes of tubular cells induced by urinary protein
In general, there are many kidney disease in the presence of urinary protein hyperproliferation, which represents a non-adaptive response, can lead to renal failure.
Toxicity of urinary protein on proximal tubule cells
When the occurrence of urinary protein, protein in renal tubular epithelial cells into lysosomes increased, the activity increased, suggesting that the lysosomal protein spilled into the tubular cytoplasm, subsequent cell injury can stimulate inflammation and scar formation.
Urinary protein causes interstitial hypoxia exacerbation
Urinary protein reabsorption, digestion of large amounts of protein requires extra energy, can cause tubular cells hypoxia, resulting in tubular cell damage.
What are the hazards of nephritic syndrome proteinuria? Through the above description, I believe we have a certain understanding of the lack of urinary protein in patients with nephrotic syndrome have a great impact, so patients should pay attention to it and active treatment.
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