Nephrotic syndrome is characterized by high degree of edema, a large number of proteinuria, hyperlipidemia, hypoproteinemia, and "three high and one low" typical clinical manifestations. Among them, a large number of proteinuria is an indispensable symptom in the diagnosis of nephrotic syndrome. Glomerular filtration membrane permeability changes is the basic cause of proteinuria formation in nephrotic syndrome. In the case of disease, the negative charge barrier of the filtration membrane is impaired, the mechanical barrier makes the membrane structure and function complete been destroyed.What are the dangers of proteinuria in patients with nephrotic syndrome?
First, prolonged, massive proteinuria of nephrotic syndrome results in massive loss of plasma proteins and causes hypoproteinemia. There are the following effects:
The increase of hyperlipidemia is positively related to hypoproteinemia, manifested as blood viscosity, promoting thrombosis, embolism complications, will also increase cardiovascular system complications, and may promote glomerulosclerosis and renal tubules The occurrence of lesions, promote chronic progression of renal disease. Immunoglobulin decreased caused by low immunity, easy to cause infection; loss of metal-binding protein can cause trace elements; drug-binding protein may affect the pharmacokinetics of certain drugs, affecting drug efficacy; endocrine binding protein can induce endocrine disorder.
Finally, children often suffer from minor lesions of nephrotic syndrome, a large number of proteinuria is mainly due to glomerular filtration membrane charge barrier damage caused. Long-term hypoproteinemia can lead to malnutrition, affecting the growth and development of children.
Beijing In China