Why do most patients with nephrotic syndrome appear edema? The occurrence of edema is related to the formation of proteinuria. Firstly, the mechanism of proteinuria is discussed.
The causes of edema in patients with nephrotic syndrome.Various kinds of pathological damage lead to impaired glomerular inflammation, including local microcirculatory disorders, ischemia and hypoxia injury and renal vascular endothelial cells of these pathological changes, renal cells damage caused by mesangial cell proliferation and mesangial matrix and basement membrane filtration pore increases or atresia, or basement membrane rupture, and mechanical, electric charge barrier injury. This will enhance the permeability of plasma protein leakage amount. The leakage of plasma albumin greatly exceeds the reabsorption capacity of the renal tubules and forms large amounts of proteinuria.After a large number of proteinuria generated, the concentration of protein in the blood of the human body will be reduced, it will lead to human hypoproteinemia, blood, plasma colloid osmotic pressure will drop. This means that the osmotic pressure in the blood is greater than that in the tissue, so that the water in the blood will permeate into the interstitial space, and the more water in the tissue, the more there will be edema.
The causes of edema in patients with nephrotic syndrome.On the other hand, the cause of edema is related to the reduction of glomerular filtration function, and the progression of nephrotic syndrome is the process of renal fibrosis. Has not been controlled, intrinsic kidney cells (especially in renal interstitial fibroblasts) will change phenotype in some renal toxicity factor and growth factor secretion and synthesis under the action of a large number of ECM, ECM and the accumulation of surplanted healthy nephron, lead to glomerular sclerosis and renal tubule fibrosis. Renal filtration loss, to the organization should be excreted water can not be excreted, resulting in tissue edema, and also a large amount of urination or urination can not be performed.
The above is the causes of patients with nephrotic syndrome edema, if patients with physical discomfort symptoms, it is timely to the hospital for treatment, to avoid missing the best treatment time, if you have a kidney problems, you can consult our online expert, our experts will give reply as soon as possible.
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