The routine diagnosis of nephrotic syndrome

The routine diagnosis of nephrotic syndrome

In 1995, the National Conference on nephrology was pided into two types according to the clinical manifestations of nephrotic syndrome caused by primary glomerulopathy. Diagnostic criteria are as follows:
Type I: features with nephrotic syndrome without hypertension, centrifuged urine red cells per high-power field number <10, no anemia, no persistent renal dysfunction, urinary protein is usually highly selective, urinary protein selectivity index spl<0.1, urinary fibrin degradation products FDP and complement C, normal.
Type II: usually accompanied by hypertension, hematuria or renal dysfunction, nephrotic syndrome can be atypical, urinary FDP and C3 are often higher than normal, urine protein is non selective. AP
Nephrotic syndrome type I is also known as simple nephrotic syndrome, nephrotic syndrome type II, also known as nephritis type nephropathy. I can be found in any age, but the majority of children and juveniles, after the age of 15 was significantly reduced, type II is more common in adults; I type hematuria not only rare and mild, short time, type II hematuria is a long time continuous presence, more severe, even gross hematuria; type I with high blood pressure rare, even if there is a lesser degree, was transient, especially hematuria and hypertension coexist situation is extremely rare, type II is common; I type renal function change is light, there was a transient, type II renal function changes significantly, which is also prone to anemia; I type FDP were measured repeatedly in recent days less than 1.25ug / ml, type II is increased and not decreased; I sensitive to corticosteroid and cytotoxic drugs), type II is not sensitive; if the renal biopsy, pathological changes of type I for the majority of minimal change disease and mild mesangial proliferative glomerulonephritis, Type II showed other pathological changes.
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