The application of glucocorticoid in nephrotic syndrome, hormone therapy is an essential link, use it for relief of the pain of the patient in a certain extent, improve the curative effect in the short term, but no control of hormone application as if opened the "box" Pandora, bring people in happiness at the same time, also attracted a disaster, the patients had severe symptoms of irreversible:
1 、 long-term over physiological dosage of glucocorticoid can cause disorders of metabolism of water, salt, sugar, protein and fat, and so on. Manifested as central obesity, resulting in calcium absorption disorders, resulting in osteoporosis, severe fractures can occur spontaneously.
2, glucocorticoids can reduce the body's ability to defend the disease, is conducive to bacterial growth, reproduction and proliferation, induced or exacerbated infection.
3, glucocorticoids promote decomposition of protein, can delay the formation of granulation tissue, prevent trauma or surgical wound and ulcer healing.
4, glucocorticoids have the effect of against growth hormone, long-term use of children can inhibit bone growth and protein synthesis, affecting growth and development, pregnant women can also cause fetal malformations.
5, long-term application of glucocorticoid treatment, after the symptoms of basic control, such as reducing too fast or sudden withdrawal, the original symptoms may occur or increase rapidly, known as "rebound" phenomenon". Some of the original disease without symptoms, such as myotonia, muscle pain, joint pain, said the withdrawal symptoms (or withdrawal syndrome).
In addition, long-term use of glucocorticoids can cause adrenal cortical atrophy or dysfunction, induce and aggravate ulcers, and even cause neuropsychiatric symptoms, which cause great obstacle to rehabilitation.
In short, hormone treatment is only a formality, does not solve the real problem, make "no overall plan for a fundamental transformation" taboo, so the application of hormone to a certain amount, can not blindly pursue the curative effect and a large number of application of hormone, patients are not only staring at the laboratory indicators in the treatment direction of misunderstanding.
Beijing In China