Kidney disease patients with cold little common sense
Kidney disease patients with cold little common sense. Frequently encountered clinical microscopic hematuria and urinary for a long time with the blood of patients, eliminate urinary calculi and infection, tumor and deformity, glomerulonephritis, high uric acid hematic disease, hyperplasia of prostate and bladder residual urine retention factors, such as asking the history of drug, the result is due to coronary heart disease or blood viscous, long-term use of low-dose aspirin 50 to 100 mg per day, reduce or stop the medication after a period of time, blood, urine, can reduce or disappear.
Clinically often encountered some patients, the long-term use of aminopyrine, not the west dean compound tablets, see more of the old man, every day at least 2 ~ 6 piece, even more than 10 pieces, several years or even 10 years to 20 years, and there are increasing, routine urine shows: low share, acidic PH value, a small amount of potential blood in the urine/hide blood in the urine, the microscopic hematuria, urinary RBC, protein with little or no proteinuria, normal or abnormal renal function index, mild to moderate to rule out other diseases, considering for chronic interstitial nephritis (drug), also known as analgesic nephropathy (analgesic nephropathy).
So, amidopyrine, not the west dean compound tablets what is the harm to the body?
A, first understand adverse reactions amidopyrine, not the paxil compound tablets and pharmacology and toxicology
Aminopyrine, not the paxil composite plate (common name), somidon piece (in general), compound preparation (phenobarbital amino than Lin Fei paxil + that + + caffeine).
Kidney disease drugs cold common adverse reactions
In composite amino than Lin Fei paxil and has obvious adverse reactions. Taking amidopyrine happen vomiting, rash, fever, sweating a lot, stomatitis, and so on, some will lead to the lack of neutrophils, aplastic anemia, exudative erythema, epidermis exfoliative dermatitis, the glans penis erosion, etc. Long-term use of phenacetin can cause renal papillary necrosis, interstitial nephritis and acute renal failure, and may even induce carcinoma of the renal pelvis and bladder cancer, can also cause dependence on drugs. Phenacetin also easy to make the formation of methemoglobin hemoglobin, blood carry oxygen, a decrease in the ability of lead to purple purple, also can cause hemolysis, liver damage, and have certain toxicity in the retina.
Matters needing attention
1. This product is used for a long time, can lead to kidney damage, severe cases can lead to a nipple necrosis or uremia, and may even induce carcinoma of the renal pelvis and bladder cancer. Should not be used for a long time, in order to avoid the lack of neutrophils, use more than one week to check blood picture regularly.
2. Amidopyrine hydrochloric acid in gastric juice and food, can form the carcinogenicity of nitroso compounds, especially the nitrosamines, which have potential carcinogenicity.
3. Long-term use can lead to dependence and tolerance.
4. All sorts of traumatic pain and visceral smooth muscle spasm is invalid.
Pharmacology and toxicology
Compound antipyretic analgesics. Amidopyrine than the west dean and hypothalamus inhibition of prostaglandin synthesis and release, returned to normal temperature regulating center of the reaction of sensory neurons and antipyretic effect; At the same time also by inhibiting prostaglandin synthesis, analgesic effect. Amidopyrine and inhibiting prostaglandin synthesis and release of local tissue inflammation, stabilize lysosomal enzymes, influence the phagocytosis of phagocytic cells and anti-inflammatory effects. Coffee because of the central nervous, excited cerebral cortex, improve the external inductance, and cerebrovascular contraction, enhance the influence of the former two drugs to relieve headaches. Phenobarbital has sedative, hypnotic and anticonvulsive effect, can enhance the analgesic action of amino Lin Fei than the west, and prevention of fever caused by convulsions.
Second, painkillers kidney damage
Many analgesic drugs have different degree of kidney damage, studies have shown that long-term use of low-dose aspirin may cause kidney damage. The renal damage that is present in most aspirin is reversible, in the early detection, timely withdrawal can be back to normal. Therefore, especially the elderly, patients with long-term use of aspirin, should be regularly check the routine urine and kidney function.
Someone think that paxil compound aminopyrine, tablet computer prices are low, and easy to get, body slightly unwell, such as a toothache, headache, back pain, joint pain, dysmenorrhea, stomach cramps, and so on, eat amidopyrine, not the west dean compound tablets, long-term use of dose increases, and even become dependent. Aminopyrine, that was, however, the pharmacology and toxicology of compound tablet, adverse reactions, as described above, can use for a long time.
Antipyretic analgesics is the main mechanism of the inhibition of prostaglandin synthesis of inflammatory mediators, which play a role, anti-inflammatory, anti-rheumatism and antipyretic analgesics. By reducing the expansion of blood vessels prostaglandins cause kidney tissue ischemia and renal tubular interstitial chronic inflammation. Analgesic metabolites in the renal medulla highly concentrated in the renal tubules have direct toxic effect, damage renal tubular epithelial cell membrane, and cause renal tubule degeneration, necrosis and atrophy. Should see the prostaglandin synthesis, renal vascular disease, main show is renal vasoconstriction, reduce renal blood flow and glomerular filtration rate lower, will lead to ischemic renal injury, high water retention of sodium and potassium, if appear afore-mentioned performance, can appear kidney failure, because it is caused by the drugs, so it is also called drug-induced renal failure.
Analgesic nephropathy (an analgesic nephropathy) : a large number of long-term abuse painkillers (mainly nonsteroidal antipyretic analgesics or caffeine, codeine), chronic renal interstitial injury, caused by chronic progressive renal tubular interstitial disease, appear nipple necrosis, interstitial nephritis, advanced renal failure, called analgesic nephropathy (a).
Has now been confirmed that could lead to drugs, including aspirin, not the west, salicylamide, antipyrine, amidopyrine, acetaminophen, indomethacin, indomethacin, ibuprofen (Finn will possess, easy AnRuiKe Finland), bute, relieve symptoms, JiaFen acid, diclofenac (remove he Lin), healthier, caffeine, codeine phosphate, etc.
Want to continue taking painkillers more than three years, the cumulative dose of pain more than 2 ~ 3 kg a may occur. The study found that in a group, because of various reasons, including rheumatoid arthritis, gouty arthritis, etc.) oral non-steroidal analgesics accumulative total more than 1000 patients, 24.4% of patients with venous angiography, ultrasound and computed tomography (CT) confirmed the nipple necrosis of the renal pelvis.
Non-steroidal anti-inflammatory drugs (nsaids (non-steroidal anti-inflammatory drugs (nsaids) : refers to a broad categories, including corticosteroids, no anti-inflammatory, antipyretic and analgesic action of drugs.
3, therefore, kidney disease and the special crowd cold drugs should be paid attention to what matters?
1. Elderly patients, heart disease, high blood pressure, hyperthyroidism, glaucoma, patients with prostatic hypertrophy dysuria, emphysema and other lung diseases, should consult the pharmacist or doctor before the application of cold medicine.
2. Who drive machine, cars, boats, or other mechanical equipment operation WeiXiuZhe ban cold medicines containing sedation during work time.
3. If the patient only sneezing, stuffy nose, stream qing no symptoms, such as fever, muscle pain, headache, does not advocate using cold medicines containing antipyretic analgesics, lest cause allergies and other adverse reactions. When the fever diagnosis for certain, is usually more than 38.5 ℃, can choose febrifuge. Children have a fever more than 39 ℃, antipyretic drug application. Has obvious headache, muscle pain, joint pain, etc., application of antipyretic analgesics, etc.
4. If the original kidney disease, as far as possible need not or pain medicine carefully.
5. During the cold war, nourish and not proprietary Chinese medicine.
6. Antipyretic analgesic drugs, alcohol is banned.
7. Drink plenty of water, diligent micturition, increase urine output.
8. Pay attention to rest and avoid fatigue.
9. Bacterial infection, can use under the guidance of the prescription of antibiotics.
Beijing In China