In the nephrotic syndrome in hormone therapy use of glucocorticoids is an indispensable link, to a certain extent, can alleviate the pain of patients, improve the curative effect in the short term, but no control of hormone application as if to open a "Pandora's box", to bring happiness to the people at the same time, also attracted a disaster the patients had severe symptoms, irreversible:
The ability of glucocorticoids can weaken the body's defenses against disease, is conducive to the growth of bacteria and proliferation, induce or aggravate infection; application of glucocorticoid long-term large dose can cause water, salt, sugar, protein and fat metabolism, such adrenocortical hyperactivity disorder. For central obesity, resulting in impaired absorption of calcium, causing osteoporosis, severe cases can occur spontaneous fracture; glucocorticoid against growth hormone action, growth and protein synthesis in children's long-term use can inhibit bone, affect the growth and development, pregnant women can also cause fetal malformation; glucocorticoids promote protein decomposition can delay the formation of granulation tissue, prevent trauma or surgical wound and ulcer healing; long-term glucocorticoid treatment, the symptoms of the basic control, such as reduction too fast or sudden withdrawal, the original symptoms can occur or worsen rapidly, known as the "rebound phenomenon". Some of the original disease without symptoms, such as myotonia, muscle pain, joint pain, said the withdrawal symptoms (or withdrawal syndrome).
In addition, long-term use of glucocorticoids can cause adrenal cortical atrophy or dysfunction, induce and aggravate ulcers, and even cause neuropsychiatric symptoms, which cause great obstacle to rehabilitation.
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