Pathological classification of nephrotic syndrome in children
1, small lesions
Clinical manifestations: 2-6 years of onset, boys are more; slow onset, common viral upper respiratory tract infection before the onset; mainly for edema, from the face of the affected body, gradually increase, serious can't open my eyes, ascites, pleural effusion, can cause breathing difficulties. Hypertension rare.
Diagnosis: according to a large number of proteinuria, hypoalbuminemia, hypercholesterolemia and edema four characteristics and age of onset.
2, mesangial proliferative glomerulonephritis
Clinical manifestations: in addition to the four characteristics, most of the children with microscopic hematuria, but also can be a gross hematuria, part of the high blood pressure, a small number of transient renal involvement.
Diagnosis: four characteristics and the age of onset for school-age children and adolescents, with occasional mild temporary glomerular hematuria, microscopic examination, immunofluorescence test negative, electron microscopy showed extensive fusion of epithelial foot processes. Some patients with severe glomerular sclerosis, hyaline degeneration may occur.
3, focal segmental glomerulosclerosis
Clinical manifestations: out of the four features, often accompanied by microscopic hematuria, occasionally high blood pressure, some of the onset of the disease.
Diagnosis: the diagnosis depends on renal biopsy, there should be more than 10 glomerular.
4, membranous nephropathy
Many secondary, rare in children.
5, proliferative glomerulonephritis
Clinical manifestations: in addition to the four characteristics, the onset of high blood pressure, children with pale, fatigue, anemia and renal function is not completely parallel.
Diagnosis: children with hematuria, renal function is not parallel, anemia and persistent low complement of children, should be early diagnosis of renal biopsy.
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