Nephrotic syndrome highly edema due to:
Why edema with nephrotic syndrome?
(1) plasma colloid osmotic pressure reducing: blood vessels on both sides of the exchange of bodily fluids from its inside and outside the adjustment of the osmotic pressure. Osmotic pressure including crystal osmotic pressure and colloid osmotic pressure, the former from crystal material (mainly the electrolyte), because of its free through the capillary wall, so not much effect on vascular fluid exchange inside and outside; The latter mainly from protein (mainly albumin), due to not freely through the capillary wall, so it is the main factor of vascular fluid exchange inside and outside. Nephrotic syndrome, due to the plasma lost large amounts of protein in the urine, hypoalbuminemia, caused by the plasma colloid osmotic pressure is reduced, when the normal 3.3 ~ 4 kPa fell to 0.8 ~ 1.1 kPa, intravascular moisture to high permeability of interstitial fluid movement, and edema.
(2) the effective blood volume reduction: plasma offshoring moisture reduce effective blood volume, which led to the following changes in the body: by volume receptor increase antidiuretic hormone (ADH), renal tubular reabsorption more water; Through excited renin - angiotensin - aldosterone system, producing secondary aldosteronism, increase renal tubular to sodium reabsorption. Natriuretic factor, reduce kidney platoon sodium. So the body water and sodium retention, further aggravating the edema.
Once got the edema of nephrotic syndrome, should be given to oedema, not just because it affect beautiful, the most main or it will aggravate the water load of the heart, causing heart failure.
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