Pyelonephritis is more common in chronic patients. Such patients can be due to various causes of recurrent, frequent urination, urgency, dysuria, hematuria, symptoms such as burning. Urine routine examination is abnormal, urine culture can find pathogenic bacteria. But some of the patients had severe symptoms, but there was no positive bacterial culture in urine. Clinically, such cases are not uncommon, especially in patients with focal or healed pyelonephritis, and urine routine is low in number or sterile.
During pyelonephritis does not appear bacterial urine:
The most common reason is that the use of anti-inflammatory drugs and chemotherapy inhibits the activity of bacteria.
Obstruction of the affected ureter causes the bacteria to not be excreted with urine.
Urine pH (PH) below 5 or high urine dilution (urine specific gravity below 1.003) is not conducive to the growth of bacteria.
Rapid urine flow causes bacteria to grow inorganic, or some bacteria grow slower or less easily to reproduce.
There is also a theory that chronic pyelonephritis is a sterile disease, which begins with bacterial infection, and then disappears, and the infection is maintained by persistent or autoimmune mechanisms of bacterial toxins.
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