Abnormalities of protein and quantity in urine are not only an indicator of disease, but an independent factor involved in the pathological process of the kidney. The levels of proteinuria in various kidney diseases are closely related to the rate of progression of chronic renal failure. Any therapeutic intervention that reduces proteinuria is beneficial to slowing down the progression of kidney disease. Although proteinuria is involved as an independent factor in renal disease, proteinuria can also damage the kidneys. Manifested in the following aspects:
The urine protein has a toxic effect on glomerular mesangial cells, patients after enter to renal failure stage, there will be a large amount of plasma protein in glomerular mesangial deposition, deposition of these macromolecules in the mesangial area can cause mesangial cell damage, proliferation of mesangial cells and mesangial matrix production increased, leading to glomerular sclerosis.
Urinary protein can damage the renal tubular interstitium, and a small amount of small molecular protein filtered by normal glomeruli is absorbed near the renal tubular epithelial cells and decomposed in the lysosomes. Under pathological conditions, glomerular permeability increased so that a large number of plasma protein leakage into the tubular lumen, proximal renal tubular epithelial cell excessive resorption of albumin resulted in increased lysosomal activity in the cytoplasm, can cause cell damage.
Large amounts of proteinuria increase the reabsorption of renal tubules and increase the production of ammonia, while the production of ammonia in renal tissue also plays a role in progressive interstitial lesions. In addition, reabsorption and digestion of large amounts of protein require additional energy, which can cause hypoxia in tubule cells and increase in oxygen free radicals, causing tubular cell damage.
So those patients with frequent proteinuria must pay attention to it. However, chronic nephritis is only one of the reasons leading to such symptoms, so the specific situation or to go to the hospital for examination.
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