Analgesic abuse nephritis is caused by analgesic nephritis, also known as analgesic abuse nephropathy, the pathological features of renal papillary necrosis and chronic tubulointerstitial inflammation.
Because of the toxic effects of drugs and the inhibition of vasodilation, ischemic necrosis of the renal papilla is the first cause of renal tubular necrosis and then inflammation of the renal tubules and interstitium. (1) the size of the double kidney decreased slightly, the cortex became thinner, and the necrosis of the renal papilla occurred in different degrees, and calcification was observed in the naked eyes. (2) focal or necrosis of renal papilla under microscope. Cortical tubules atrophy, interstitial fibrosis, and lymphocytes and macrophages infiltration.
The most common clinical manifestations were chronic renal failure, hypertension and anemia. Anemia may be related to the damage of the metabolites of analgesic drugs to red blood cells. Laboratory tests showed a decrease in urine concentration. Renal papillary necrosis can cause gross hematuria and renal colic. Imaging findings show necrosis and calcification of the renal papilla. Stopping the use of related analgesics can stabilize the condition and may restore kidney function.
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