Penicillin is effective drug control various infectious diseases, because of high efficacy, toxicity is relatively low, in addition to general allergic reactions, the use of commonly used dose not have adverse reactions, but the application of excessive doses, there is a variety of symptoms of poisoning, which penicillin causes interstitialnephritis?
There are many types of drugs that can cause interstitial nephritis, and antibiotics (penicillins, etc.) and NSAIDs are the most common. The drug acts as hapten and combines with protein (carrier) in vivo, causing hypersensitivity (including bacterial and humoral immune response), causing renal interstitial and tubular lesions. Non steroidal anti-inflammatory agents may also contribute to glomerular minimal change nephropathy.
Almost all kinds of penicillin may cause interstitial nephritis, but the most common is two methoxy penicillin. In recent years, it seems that amoxicillin (amoxicillin) and piperacillin are also increasing. The incubation period is usually 2 weeks, but can range from 2 days to several weeks. Children are common, the dosage is not related to the onset.
In addition to the presence of acute allergic glomerulonephritis, some of the cases presented with renal failure, sodium chloride, acidosis, and hyperkalemia. The mechanism of the disease is associated with penicillin hapten binding to the renal tubule basement membrane, resulting in the formation of antibodies against the renal tubular basement membrane. Renal function is expected to recover after a few weeks of withdrawal and dialysis is needed in a small number of cases.
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