Which penicillin causes interstitialnephritis?

Which penicillin causes interstitialnephritis?

Penicillin is effective drug control various infectious diseases, because of high efficacy, toxicity is relatively low, in addition to general allergic reactions, the use of commonly used dose not have adverse reactions, but the application of excessive doses, there is a variety of symptoms of poisoning, which penicillin causes interstitialnephritis?

There are many types of drugs that can cause interstitial nephritis, and antibiotics (penicillins, etc.) and NSAIDs are the most common. The drug acts as hapten and combines with protein (carrier) in vivo, causing hypersensitivity (including bacterial and humoral immune response), causing renal interstitial and tubular lesions. Non steroidal anti-inflammatory agents may also contribute to glomerular minimal change nephropathy.

Almost all kinds of penicillin may cause interstitial nephritis, but the most common is two methoxy penicillin. In recent years, it seems that amoxicillin (amoxicillin) and piperacillin are also increasing. The incubation period is usually 2 weeks, but can range from 2 days to several weeks. Children are common, the dosage is not related to the onset.

In addition to the presence of acute allergic glomerulonephritis, some of the cases presented with renal failure, sodium chloride, acidosis, and hyperkalemia. The mechanism of the disease is associated with penicillin hapten binding to the renal tubule basement membrane, resulting in the formation of antibodies against the renal tubular basement membrane. Renal function is expected to recover after a few weeks of withdrawal and dialysis is needed in a small number of cases.

 

上一篇:Lupus nephritis in addition to hormones, Chinese medicine ca
下一篇:Drugs which cause interstitial nephritis

Hot News

Latest News

TCM Therapy

Diet conditioning for nephropathy

Diet conditioning for nephropathy

Kidney disease is recognized as a chronic disease i ...

can kidney transplant cure Kidney disease?

can kidney transplant cure Kidney disease?

Myth.Hormones can cure the disease Many patients at ...

  Lupus nephritis patients do not come to menstruation

Lupus nephritis patients do not come to menstruation

Lupus erythematosus nephropathy is one of autoimmun ...

Chinese medicine treatment of pyelonephritis also have taboo

Chinese medicine treatment of pyelonephritis also have taboo

Pyelonephritis (pyelonephritis) refers to inflammat ...

Tags

Leave a Message

看不清?点击更换

Contact