Glomerular filtration rate and influencing factors

Glomerular filtration rate and influencing factors

Glomerular filtration rate and its influencing factors. Glomerular filtration rate (GFR) is a measure of the total amount of filtrate formed by the kidneys of all nephroblasts per minute. Glomerular filtration rate is proportional to the pressure gradient in the glomeruli, so the pressure change will change the glomerular filtration rate. Glomerular filtration rate is also an indicator of urine production, increased glomerular filtration rate will increase urine production, and vice versa.

Glomerular filtration rate and its influencing factors. It is generally believed that changes in systemic blood pressure will lead to changes in glomerular capillary pressure, leading to changes in glomerular filtration rate. In normal people, because the kidneys are automatically adjusted, this will not happen. The automatic regulation of the kidneys involves the internal feedback mechanism of the kidneys that cause the infusion or contraction of the incoming arteries to resist blood pressure changes and maintain a stable glomerular filtration rate. For example, if the mean arterial pressure is elevated, renal autoregulation can lead to afferent arterial contractions, preventing increased stress from being transmitted to glomerular capillaries, and maintaining glomerular filtration rate not increasing. It should be noted that automatic renal adjustment is usually used to maintain the stability of glomerular filtration rate over a wide range of blood pressure.
Glomerular filtration rate and its influencing factors. There are many factors that affect the glomerular filtration rate, including glomerular filtration membrane permeability and the total filtration area, effective filtration pressure, renal blood flow. No matter which of them has problem will affect the glomerular filtration, so usually must pay attention to own physical condition, take regular physical examination, to have early detection of disease and take timely treatment.

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