What drugs are used to treat lupus nephritis?

What drugs are used to treat lupus nephritis?

Many patients friends do not know when they are sick, what medicine is most effective? A kidney specialist in Beijing Tongshantang Hospital of Traditional Chinese Medicine said, drug therapy for systemic lupus nephritis, according to clinical symptoms of different patients to prescribe. Then, there are some differences in the use of lupus nephritis in the treatment of lupus nephritis. For each type of clinical symptoms, the treatment of lupus nephritis is described as follows:
First, for mild systemic lupus erythematosus (if only skin rashes, or joint symptoms) and serological abnormalities, if normal urinalysis, renal biopsy showed normal or mild glomerular lesions, as appropriate, use of non steroidal anti-inflammatory drugs improve symptoms, drugs for the treatment of lupus nephritis, generally without glucocorticoid or cytotoxic drugs, closely tracking changes; if abnormal urine, renal biopsy showed focal segmental glomerular mesangial hyperplasia accompanied by segmental necrosis and crescent formation and focal glomerulosclerosis, with medium and small dose of corticosteroids (such as prednisone 20 ~ 40mg/d), cytotoxic drugs with discretion or tripterygium.
Second, severe systemic lupus erythematosus (such as fever, joint pain, weakness and lesions involving the serosa, rapid heart, lung, liver, hemopoietic organs and other tissues) with acute nephritis syndrome or acute nephritis syndrome, renal biopsy showed diffuse proliferative glomerulonephritis and crescentic glomerulonephritis, renal function a progressive decline, drugs for the treatment of lupus nephritis, should be given to standard hormone therapy plus CTX shock treatment; or methylprednisolone treatment, daily 1.0g, intravenous 3 ~ 5 days for a course of treatment, after moderate doses of prednisone to maintain 7 ~ 10 days, when necessary, can be repeated, generally not more than 3 courses.
The above method is ineffective or serious illness, can consider plasmapheresis; do not use CTX to try cyclosporine A, mycophenolate mofetil; accompanied by severe acute renal failure, emergency dialysis serious high blood volume, heart failure, make it out of danger, and create conditions for time for medicine physical therapy.
Third, it showed no signs of protein in the urine (urine protein "2g/24h), lupus nephritis therapeutics is the use of corticosteroids, cytotoxic agents are used to add Tripterygium combined with prednisone also have certain curative effect; for asymptomatic hematuria, available Tripterygium (conventional dose or double dose) or CTX treatment; the best conditions were according to the drug selection type of renal pathology.
Fourth, a pathological type of nephrotic syndrome in patients with lupus nephritis, but not many red blood cells in urine, kidney function, or renal biopsy showed membranous lupus nephritis, lupus nephritis therapeutics should be preferred prednisone 0.8~1.0mg/kg.d, if 2 to 4 weeks after the results are poor, with CTX, when associated with renal function loss, severe hypertension, renal biopsy showed glomerular hyperplasia or pathological change, should be given to standard hormone therapy plus CTX shock treatment.
Fifth, for fixed proteinuria without systemic lupus erythematosus manifestations, or azotemia and renal pathology in chronic disease; prednisone and cytotoxic drug treatment with drugs for the treatment of lupus nephritis is generally not long.
Sixth, end-stage lupus nephritis is treated by chronic renal failure.
More than just a drug treatment method, as lupus nephritis patients in the hospital clinical treatment process more quickly relieve symptoms but can not solve all the problems fundamentally, or to cooperate with the doctor. If you have any further questions, please contact our online doctor or leave a message for us. We will reply to you as soon as possible.
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