Therapeutic principles of glomerular nephritis

Therapeutic principles of glomerular nephritis

Chronic glomerulonephritis is a kind of nephritis, the disease is difficult to treat, long course of disease, and after treatment is easy to relapse, plagued by a lot of people. The study found that the disease occurs in young adults, so that patients in the state of medicine for many years, the patient's physical and mental brought great harm, we specifically talk about the treatment of chronic glomerulonephritis.

1, the control of dietary protein

In patients with renal dysfunction should be early with low protein diet, general protein intake limit at 0.6 ~ 0.8g/ (kg - D), and the addition of essential amino acids, such as the contract (a-ketoacid). At the same time, appropriate increase in sugar to prevent negative nitrogen balance. If the patient's renal function is normal, and there is a large amount of proteinuria, then the direct relaxation of protein intake to 0.8 ~ 1.0g/ (kg * D).

2, active control of hypertension

Chronic nephritis, the survival of kidney units in compensatory high blood pressure, hypertension can further aggravate the disease. Therefore, we should actively control high blood pressure and prevent the deterioration of renal function. In recent years, it has been confirmed that angiotensin converting enzyme inhibitor (ACEI) and calcium antagonists are effective in the treatment of hypertension and delay the deterioration of renal function. Most of these patients have been treated with these two drugs as first-line antihypertensive drugs. Beta blockers can reduce cardiac output, but do not affect renal blood flow and GFR, there is a reduction in renin, renal hypertension can be treated. Alpha 1 receptor blocking drugs may dilate arterioles and venules, but should prevent orthostatic hypotension.

3, angiotensin converting enzyme inhibitor (ACEI)

In addition to the positive antihypertensive effect, the drug can also reduce the internal pressure of the glomerulus, and has the function of delaying the deterioration of the renal function, reducing the urine protein and reducing the glomerular sclerosis. Clinical commonly used ACEI, such as Benner Pury. The common side effects of hyperkalemia (especially renal insufficiency), skin rash, itching, dry cough, taste loss, rare neutropenia.

4, anticoagulation and platelet depolymerization drug

Most studies confirm that the anticoagulant and platelet depolymerization drug can reduce the renal pathological damage, delay the progress of renal function nephritis. It can be used for a long time in the condition of clear high coagulation state and some kinds of pathological types (such as membranous nephropathy and mesangial proliferative glomerulonephritis).

5, prevention and treatment can cause kidney damage and other factors

Infection, fatigue, pregnancy, and the use of nephrotoxic drugs are likely to damage the kidneys, resulting in deterioration of renal function, should be avoided.

6, ACEI and (or) class ARB drugs

Such as Benap and 10mg, 1 times a day; according to the illness can adjust the dosage to 40 ~ 60mg and (or) Dioan tablets 1 times a day; and 80mg, according to the condition which can adjust the dosage to 160 ~ 320mg to reduce blood pressure, reduce proteinuria and protect renal function, but should pay attention to the monitoring of electrolytes and renal function. Such as accompanied by hyperlipidemia, delicious clothing Bo accounted for, 10mg, 1 times a day. Such as abnormal renal function, creatinine value is high, can be treated with niaeduqing, 5g, 4 times / day, haikunshenxi capsule, 2 capsules, 3 times daily.

7, intravenous drip improve microcirculation drugs

Such as 10% glucose 250ml+ Yue Xin 40 ml continuous static point for 14 days. If patients with abnormal renal function, can be static point 10% glucose 500ml+ kidney Kang Injection for 60 ~ 100ml for a period of 30 days.

8, hormones and cytotoxic drugs generally do not advocate the use of

Patients with normal renal function or only mild damage. Normal kidney volume, urinary protein than 2.0g/24h and pathological types of mild mesangial proliferative glomerulonephritis, minimal change disease is lighter, such as trial of hormone and cytotoxic drugs without contraindications, invalid gradually removed.

See the introduction of your chronic nephritis treatment should be clear now, you must take a look at Oh, in addition, in addition to drug treatment, it is very important to the daily diet, diet, low salt diet, do not eat hot food, don't take drugs, damage to renal function in all, from life to start, to prevent recurrence of the disease.


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