Chronic glomerulonephritis is a kind of kidney disease, is not an independent disease, for the cause of chronic glomerulonephritis, a lot of people are very confused also want to know, understand the cause of nephritis help in time treatment. So, what are the causes of chronic glomerulonephritis?
Etiology of chronic glomerulonephritis. Before the onset with upper respiratory infection or other infections, a chronic nephritis may be caused by acute poststreptococcal glomerulonephritis evolved, but the majority of chronic nephritis and acute nephritis is not persistent, while the other primary glomerular diseases directly in development, which belongs to the onset of chronic nephritis.
According to the different pathological types, chronic glomerulonephritis can be pided into the following types:
Mesangial proliferative glomerulonephritis (IgA) is a kind of mesangial proliferative glomerulonephritis and non IgA mesangial proliferative glomerulonephritis;
Chronic glomerulonephritis, membranous nephropathy;
Focal segmental glomerulosclerosis in chronic glomerulonephritis;
Chronic glomerulonephritis and mesangiocapillary glomerulonephritis;
Chronic glomerulonephritis and proliferative sclerosing glomerulonephritis.
Pathogenesis of chronic glomerulonephritis:
Due to chronic nephritis is not an independent disease, its pathogenesis is different, most of immune complex disease, by circulating soluble immune complexes deposited in glomeruli, or by antigen and antibody in the glomerulus in situ formation of immune complexes, activation of tissue injury. It is also possible to activate complement through the "bypass system", which is caused by the formation of a series of inflammatory reactions, such as bacterial toxins and metabolites that are deposited in the glomerulus.
In addition, non immune mediated renal damage may play an important role in the occurrence and development of chronic nephritis:
Renal glomerular sclerosis caused by glomerular lesions in the patients with chronic glomerulonephritis;
Chronic glomerulonephritis: compensatory changes in renal hemodynamics lead to glomerular damage. The glomerular filtration rate is increased when the renal glomerulus is involved, and the high perfusion and high filtration state can make the glomerular sclerosis and renal failure;
Renal glomerular sclerosis induced by hypertension in chronic glomerulonephritis. Long term hypertension caused by ischemic changes, leading to renal artery stenosis and occlusion, accelerated glomerular sclerosis, hypertension or by increased glomerular capillary hydrostatic pressure, caused by glomerular hyperfiltration, accelerated glomerulosclerosis;
The overload state of chronic glomerulonephritis mesangial. Normal glomerular mesangial cells have the function of phagocytosis and clearance of immune complex, but when the load is too heavy, it can lead to the proliferation of mesangial matrix and cell, and finally to harden
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