Many patients with initial nephrotic syndrome say, "what is nephrotic syndrome?" Why isn't it nephritis?" In fact, nephrotic syndrome is characterized by large amounts of proteinuria (24 hours, more than 3 urine protein). 5 grams) hyperlipidemia, and clinical syndrome of varying degrees, is a further diagnosis than nephritis. The common causes of primary glomerular disease (such as primary glomerulonephritis, focal glomerular sclerosis etc.), secondary glomerulonephritis (such as lupus nephropathy, diabetic nephropathy) and secondary infection (such as bacteria and viruses), circulatory system disease, drug poisoning.Today we come to talk about the difference between nephrotic syndrome and nephritis what is it.
In the early stage of nephrotic syndrome, the basement membrane lesion is mild. With the progression of the lesion, a large amount of protein is excreted from urine, which is an important cause of the decrease of plasma proteins. The decrease of plasma protein, especially the decrease of albumin, results in the decrease of colloid osmotic pressure and the exudation of fluid into the blood vessel, resulting in the edema of tissue and the decrease of the effective blood volume. The mechanism of hyperlipidemia in renal disease is not very clear. When large amounts of urine proteins are lost, as the synthesis of albumin in the liver increases, the synthesis of lipoproteins also increases, becoming the cause of hyperlipidemia. In addition, the decrease in lipoprotein lipase activity leads to a decrease in lipid clearance and may be partly responsible.
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