With persistent hypertension as the cause, will directly cause kidney damage caused by renal arteriosclerosis, nephron atrophy, and the emergence of a series of clinical symptoms of renal dysfunction, severe lesions may also occur in renal failure, some even become uremia, namely hypertension leads to kidney disease. Kidney disease and hypertension, the deterioration of the relationship between each other, the high blood pressure itself will cause kidney disease, kidney disease, which in turn causes an increase in blood pressure, which is a so-called vicious cycle process.
How does kidney disease affect blood pressure? Kidney is congenital, the kidney is not only a very important excretory organ, but also has a lot of endocrine functions, such as the regulation of hematopoiesis, regulating the metabolism of calcium and phosphorus, and the regulation of blood pressure. Renal regulation of blood pressure is multifaceted. There are two important functions, one is the secretion of renin, with a pressor effect, known as renin - angiotensin - aldosterone system, and the two is the secretion of renal prostaglandins, with antihypertensive effect. Under physiological conditions, a booster system, a step-down system, the two is a unity of opposites, thus maintaining the body's normal blood pressure. If this dynamic balance (relative balance) is broken, that is, excessive secretion of renin, or inadequate secretion of prostacyclin, can maintain a higher state of blood pressure.
High blood pressure, if not timely and correct treatment, will destroy the renal blood vessels, leading to insufficient blood supply to the kidneys, causing kidney damage. When the renal function is completely lost, the kidney failure. At this point the kidneys will not release the hormones that maintain the balance of blood pressure, the lack of hormones needed to make red blood cells and vitamin D. As a result, there is a higher level of blood pressure that can lead to serious complications such as stroke, heart disease, uremia, and even death. The body does not produce enough red blood cells, which can lead to anemia. Due to lack of calcium, bone will become fragile. Therefore, hypertension and kidney disease is always a vicious circle.
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