It is generally accepted that diabetic nephropathy is pided into five stages of progression from mild to severe. If prevention and treatment are not appropriate, type 1 diabetes usually progresses to the advanced stage every five years. However, type 2 Diabetes is progressing faster, usually every 3 years will go to the direction of disease progression 1.
The first is the excessive filtration of glomerular period, soaked in blood glucose, glomerular appears to be some hypertrophy, this period just to control blood sugar, the condition can be reversed, glomerular returned to normal. After entering phase 2, glomerular basement membrane (the second layer of filtration structure) began to thicken, the patient at rest in the urine of 7 nm in diameter, the normal number of albumin, but during exercise, urine in this The amount of albumin will exceed the normal value, which means that the amount of albumin per liter of urine more than 20 mg, if given the correct treatment, the period of the disease can be completely reversed, otherwise the disease will enter the third . In stage 3, glomerular basement membranes are significantly thickened. Whenever a patient is resting or exercising, the amount of albumin in each liter of urine will exceed 20 mg but less than 200 mg, and the patient must be immediately regulated Strict treatment, there is hope to completely repair the glomeruli so as to be able to recover if the patient did not pay attention or did not find that the number of albumin will exceed 200 mg, diabetic nephropathy from the condition is irreversible only one step away It's Then the disease into the obvious symptoms of irreversible period, medically called the clinical diabetic nephropathy period, this period is an ordinary urinalysis can be found in urine albumin (albumin per liter of urine has exceeded 350 mg), and glomeruli have been partially sclerosis and necrosis, patients with various symptoms of chronic kidney disease, and even within 3 years often appear ascites and pleural effusion, this period of treatment is mainly to delay the disease into the first five, that is Glomerular extensive hardening and necrosis of the uremic period.
Because the diabetic retinal microvessels, like glomeruli, are soaked in hyperglycemia for many years, the doctors found that diabetic retinopathy and nephropathy often occur simultaneously, and therefore, when the patient perceives a problem with vision , Do not neglect whether the kidney is also a disease, in short, the earlier the diabetic nephropathy, given appropriate prevention and treatment measures, then the future prognosis is better.
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