Diabetic nephropathy is one of the common complications of diabetes, but also an important cause of death in diabetic patients. The pathogenesis of diabetes is complicated, such as disorders of glucose metabolism, infection factors and so on. In addition to the above factors, the immune system is also closely related to diabetic nephropathy, low immunity will aggravate the patient's condition.
First, the application of related immunological detection method found that patients with diabetic nephropathy in the number of macrophages and normal white blood cells increased, which patients with moderate glomerulosclerosis increased more obvious, the relevant tissue by macrophages and white blood cells widely infiltration. Macrophages and white blood cells increased, means that the inflammation of the kidney will be more serious.
Second, through the application of cellular immune activated leukocyte antigen monoclonal antibody in vivo and indirect immunofluorescence method to distinguish, found in the clinical stage of diabetic nephropathy patients with over expression of activation of peripheral blood mononuclear cells. Overexpression of monocyte activators allows lymphocytes to be activated, activated lymphocytes by producing intracellular glucosidase, which breaks down the glomerular basement membrane epithelial cells and further impairs the glomeruli.
Third, glial cells in a variety of cells in the presence of interleukin 6-mRNA, interleukin 6-mRNA and membranous nephropathy is closely related, and membranous nephropathy is a major immune factors caused by kidney disease, the occurrence of interleukin 6-mRNA will cause serious damage to the renal tissue of diabetic nephropathy patients.
Through the above three points, it is easy to see when the diabetic nephropathy in patients with low immunity, the patient's renal tissue inflammation will increase, kidney damage rate will speed up. Therefore, for patients with diabetic nephropathy, enhance the body immunity for the relief of the disease is important.
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