what factors form diabetic nephropathy?

what factors form diabetic nephropathy?

Ten, what factors form diabetic nephropathy?
The factors contributing to diabetes are as follows:
Genetic factors
Most people with diabetes may not happen after renal lesions, but some of the long-term good glycemic control in patients with diabetic nephropathy can appear, the main reason is the main form of glucose transporter on the glomerular mesangial cells.
Two, hyperglycemia factors
The majority of diabetic nephropathy has close relationship with high blood glucose, when poor glycemic control in patients with body, mesangial cell proliferation caused by increased blood glucose and advanced glycation end products generated after the extracellular matrix increased, mesangial expansion, glomerular basement membrane thickening, thus promoting the occurrence of diabetic nephropathy.
Three, hypertension factors
Although there is no direct relationship between hypertension and diabetic nephropathy, but the deterioration of microalbuminuria in hypertension in the original period when the blood pressure can accelerate renal function in patients with diabetic nephropathy, and diabetic nephropathy.
Four, abnormal renal hemodynamic factors
Renal blood flow factors play a very important role in the pathogenesis of diabetic nephropathy, which may be more likely to be the starting factor of Guan Jian. General from the following four specific analysis:
1, when the high blood sugar, high capillary pressure, promote the expansion of mesangial cells, and generate dense droplets of fusion of epithelial foot processes, glomerular epithelial cell shedding from the basement membrane, resulting in high perfusion and high filtration state was the glomeruli.
2, in the glomerular basement membrane type IV collagen messenger nucleic acid increased, to the basement membrane thickening, and ultimately the formation of diffuse and nodular lesions of the system, resulting in glomerular sclerosis.
3, in the case of increased renal blood flow pressure, the increase in protein filtration, promote matrix increase, the formation of mesangial and glomerular basement membrane, resulting in nodular glomerulosclerosis.
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