Kidney damage in type 2 diabetes mellitus

Kidney damage in type 2 diabetes mellitus

The incidence of various types of kidney damage in patients with type 2 diabetes has not been clearly documented in the literature. The bias in the report may be influenced by factors such as race and region. But mazzucco g and colleagues at the University of Italy, Tori, think that the criteria used by the Centers for kidney disease in patients with kidney biopsy may be one of the factors.

They reported a multicenter study in northwestern Italy, where renal biopsies were performed in 393 patients with type 2 diabetes using a different (strict or non strict [cup]) biopsy criteria in patients with type diabetes.

Under the light microscope, immunofluorescence and ultrastructural studies, were further pided into 3 levels: Level 1: diabetic glomerular sclerosis; grade 2: diffuse vascular (arterial arteriolar sclerosis) and ischemic glomerular change; 3A: on the basis of diabetic glomerular sclerosis with other glomerulonephritis; 3B: diabetic glomerular sclerosis glomerulonephritis.

Although there was no significant difference in the proportion of patients with between the CRPS and cup criteria (15% and 16%, respectively), the incidence of the other two levels was severely affected by the renal biopsy criteria. According to CRPS and cup criteria, the incidence of grade 29% and 51%, respectively, the incidence of grade 3 and 33%, respectively, of 57% and 1. In addition, according to the cup criteria, Grade 3A cases were more common (67%); the 3B grade cases were more common () according to the CRPS criteria.

This study explains the reasons for the different data in the literature and the impact of different renal biopsy criteria on epidemiological studies.

Mazzucco g concluded that this study has the incidence of renal changes in patients with type 2 diabetes can help to clarify, and suggest the need for therapeutic approach to wider application of renal biopsy to obtain reliable prediction index and reasonable plan.

 

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