Patients with chronic renal failure are accompanied by varying degrees of anemia, and with the decline of renal function, anemia gradually increased. The pathogenesis of chronic renal failure anemia has the following aspects:
First, the reduction of erythrocyte formation:
Erythropoietin is mainly produced by glomerular glomerular cells, medullary stromal cells. Chronic renal failure, in addition to the kidneys produce erythropoietin site damage, the hemoglobin to oxygen affinity decreased, the unit hemoglobin on the oxygen utilization increased, renal ischemia is relatively serious, the main stimulus to produce erythropoietin reduced, Resulting in a significant reduction in erythropoietin production.
② toxins inhibit bone marrow:
Chronic renal failure in the blood accumulation of certain toxic substances on the bone marrow has a direct inhibitory effect, causing hematopoietic dysfunction.
③ iron power disorder:
Iron storage and reticuloendothelial system metabolic abnormalities, hemoglobin metabolism out of the release of iron is affected, the result is serum iron down and supply of bone marrow iron reduction, affecting hematopoiesis.
④ folic acid deficiency:
Chronic renal failure due to inadequate intake often cause folic acid deficiency. In addition, uremic patients with folate-binding protein increased, can be transferred to the cell to reduce the number of folic acid. Long-term dialysis patients are more likely to produce folic acid deficiency.
Second, increased red blood cell damage:
Reasons: uremia caused by hyperthyroidism caused by shortening of erythrocyte life, self-dissolution; erythrocyte metabolic disorders and erythrocyte brittleness increased, resulting in red blood cell autolysis; microvascular disease to red blood cells by mechanical damage and destruction; spleen hyperthyroidism.
Three: increase in red blood cell loss:
Chronic long-term upper gastrointestinal and lower digestive tract recessive bleeding, laboratory blood tests or dialysis in the residual blood loss, can increase anemia.
Fourth, the life of red blood cells due to retention of metabolic products and shorten the impact:
Renal failure when the coagulation dysfunction, patients often bleeding tendency, such as epistaxis, bleeding gums, gastrointestinal bleeding, after more than so, blood loss increased anemia.
The above is about the causes of anemia in chronic renal failure, if you have questions on the kidney disease need a detailed understanding, you can consult our online experts, our experts will reply to you as soon as possible.
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