The increase of serum creatinine and urea nitrogen in renal function is not necessarily the renal insufficiency, which is affected by a variety of factors.
Urea nitrogen is an important indicator of renal function examination. The formation of urea nitrogen in amino acid ammonia and carbon dioxide is produced in the liver,. Remove protein from serum components, is called the residual nitrogen, health is more than 50% of urea nitrogen. The urea nitrogen from the glomerular filtration of the organ after excretion in the urine and if the excretion of renal function deterioration, the blood urea nitrogen concentration will increase.
Creatinine is a product of muscle metabolism in the human body, the level of serum creatinine and renal function level. There is a close relationship between the normal creatinine values are male 44-106umol/L female 70-106umol/L. increased serum creatinine harm, is more than 707 uremia! Creatinine in human body is mainly through kidney glomerular filtration after renal tubular excretion in kidney. After injury, serum creatinine creatinine can not be discharged, has become one of the standard measure of renal function.
The amount of muscle tissue metabolism and kidney is the main external factors that affect serum creatinine, muscle atrophy of muscles of patients with metabolic diseases decreased, pregnant women increased protein synthesis, creatinine generation decreased, serum creatinine can be slightly lower; fever can enhance the catabolism, caused by increased serum creatinine; high protein diet can cause transient increase of serum creatinine.
The amount of protein diet, gastrointestinal bleeding, high metabolism, prerenal factors, cardiac insufficiency, renal blood urea nitrogen is mainly affected the level of external factors. Under normal circumstances, the reabsorption of urea nitrogen is about 30%-40%, a small amount of urinary urea nitrogen, side by side when dehydration, blood volume, heart failure when the reduced renal blood flow, renal tubular reabsorption function enhancement, urea nitrogen absorption increased, blood urea nitrogen concentration increased as prerenal azotemia; high protein diet, gastrointestinal bleeding, high metabolism such as fever in the generation of urea nitrogen increased, blood urea nitrogen increased.
Therefore, the increase of blood urea nitrogen and blood creatinine is not necessarily the damage of glomerular function, which should be combined with clinical.
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