To use antibiotics for chronic renal failure safe and effectively include the following:
First, the use of sensitive antibiotics for pathogens. In the choice of antibiotics should be done before the bacterial, before the results should be combined with the patient, according to the local epidemiological materials such as the use of antibiotics, to be bacterial culture results to be adjusted.
Second, according to the pharmacokinetics of antibiotics to determine the route of administration, methods and dose, in the crf, the main renal excretion of drug half-life was significantly extended, combined with the above, the administration method to be adjusted, the dose should be reduced to Drug interval to be extended. Adjust the dose of the focus of renal excretion type drugs such as aminoglycoside antibiotics, peptides and so on.
Again, should control the side effects of drugs, all kinds of side effects are mostly prone to crf. It is believed that due to renal failure caused by excessive drug concentration is the cause of side effects, it may be appropriate symptomatic treatment to prevent the occurrence of some side effects.
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