Regardless of the cause of kidney damage, once renal damage reaches a dangerous level, it is difficult to avoid the progression of the disease until the final stage of renal failure. Although the progress of damage to renal function is not completely clear, it is associated with the following important factors: including progressive immunological damage, increased glomerular filtration due to hemodynamics, dietary protein and phosphorus intake, persistent proteinuria and high blood pressure.
Such as immune complexes or antibodies against the basal membrane of the deeps, which continue to settle in the glomeruli, can lead to glomerular inflammation, so that the final scar formation.
Regardless of the mechanism that initially causes kidney damage, a high level of filtration can be a common process that causes the destruction of the glomeruli. Any cause of nephron loss can cause a disruption of the residual nephron function and structure, and an increase in glomerular blood flow. The increase in glomerular high filtration can be caused by the maintenance of kidney function, but it can also protect the mechanism of these glomeruli. The main mechanisms of damage are increased hydrostatic pressure, directly acting on the integrity of the capillaries, which leads to an increase in protein loss through the capillaries. When progression of solidification occurs, the loads of the remaining renal units increase, the formation of a vicious cycle between increasing glomerular blood flow and high filtration, induce angiotensin-converting enzyme inhibition, and a decrease in high filtration to slow the progression of the disease. A diet high in protein causes progression of renal failure, may be associated with an expansion of afferent small arterial dilatation and a high level of filtration. Conversely, a low-protein diet slows the rate of development of renal failure. The normal rate of glomerular filtration of a person is directly related to protein intake and suggests that proteins, such as limited diets, can slow the rate of progression of renal failure in patients with chronic kidney failure.