Chronic renal failure (CRF) refers to various causes of chronic progressive renal damage, resulting in renal atrophy, unable to maintain the basic function, has certain harm to the kidneys, here to see this is Rhubarb in treatment of chronic renal failure.
Since the 60s of last century, rhubarb has been widely accepted and approved for the treatment of CRF, and rhubarb is an essential traditional Chinese medicine for CRF. In recent years, many scholars have made further research on the mechanism of Rhubarb in the treatment of CRF.
(1): the purgative effect of Rhubarb in different varieties and different formulations and different active ingredients are diarrhea, rhubarb purgation effect is mainly sennosides, heating can make the rhubarb purgation effect weakened, because heating can make the combination part to free component. The purgative effect of Rhubarb in the large intestine and rhubarb is characterized by the accumulation of nutrients in the small intestine. Studies have shown that anthracene glycosides after the arrival of large intestine, the enzyme is broken down into free glycosides, stimulate the large intestine, resulting in increased emptying movement, resulting in defecation, so that the intestinal tract creatinine, urea nitrogen and other toxins excreted. Rhubarb absorbed in the small intestine, into the blood circulation, and then transported to the large intestine, stimulate the large intestine under the mucous membrane of nerve plexus, so that the deeper part of the nerve from the excitement, resulting in intestinal movement, leading to diarrhea. In addition, rhubarb can obviously inhibit the absorption of water and electrolyte in intestine. Rhubarb part removing metabolic waste in the digestive tract, improve gastrointestinal mucosal barrier function, prevent the serum endotoxin (LPS) into the blood LPS level decrease of nitric oxide synthase (NOS) activity decreased, so the generation of NO. With the decrease of NO levels in the blood, the "three high (high perfusion, high pressure and high filtration)" in renal units can be improved.
(2) effect on the urinary system: Rhubarb pharmacognosy, rhein, emodin Sujun have a diuretic effect, the effective component of rhubarb, not only has a strong inhibitory effect on Na+-K+-ATP enzyme, but also a regulator, which reduce the absorption of urine sodium increased to diuretic effect, rhubarb has better curative effect on azotemia, the urea in liver and kidney volume was 10% lower than that of renal dysfunction in rats can significantly reduce blood urea nitrogen and nitrogen can increase the excretion of metabolites; reduce the effect of Processed Rhubarb on creatinine and urea nitrogen, methyl guanine, guanidine acetate succinate salt and inorganic phosphorus were.
The above content introduces several mechanism about traditional Chinese medicine Rhubarb in the treatment of chronic renal failure, the mechanism of Rhubarb in the treatment of chronic renal failure today will be introduced here, if you have other questions, you can consult our online doctor or give us a message, we will reply to you as soon as possible.