The kidney is an important organ of drug metabolism and excretion, and the kidney damage caused by drugs is increasing. As the current variety of drugs, coupled with serious drug abuse problems, drug induced acute and chronic renal failure is increasing.
The kidney is an important detoxifying and excretory organ of the human body. Most of the drugs we take are concentrated and excreted by the kidneys. Therefore, the kidney is very susceptible to drug damage. While many people after a cold often self medication with antibiotics and antipyretic analgesic drugs, often do not understand the drug ingredients and excessive use, the effect seems to be "very good", but in fact there are many patients because of the use of drugs caused acute renal injury, renal toxicity of the most common drugs in clinical analgesic agent, aminoglycoside antibiotics, antitumor drugs, diuretics, contrast agent etc..
So what are the causes of acute renal failure?
1. lack of blood volume
(1) loss of digestive tract: such as vomiting and diarrhea.
(2) the various causes of bleeding: massive hemorrhage induced shock and insufficient blood volume, sometimes coexist, severe renal hypoperfusion, decreased glomerular filtration rate, renal tubule degeneration and necrosis is a common cause of acute renal failure.
(3) a large number of skin loss of fluid: heat stroke and a large number of sweating, not timely replenishment of blood volume.
(4) interstitial fluid loss: such as extensive burns, peritonitis, necrotizing pancreatitis, a large number of liquid into the gap, resulting in severe blood volume insufficiency, leading to kidney failure.
(5) excessive diuresis: diuresis can cause loss of water and salt loss.
2. renal hypoperfusion
Cardiovascular disease due to severe cardiac insufficiency, renal hypoperfusion is seen in: (1) congestive heart failure. (2) acute myocardial infarction: combined with cardiogenic shock or severe arrhythmia, it is more likely to combine with acute renal failure. (3) pericardial tamponade: systemic congestion at this time, seriously affecting cardiac output. (4) renal artery thrombosis or thrombosis. (5) large area pulmonary infarction. (6) severe arrhythmia.
3. peripheral vascular dilatation or infection poisoning
Peripheral vascular dilatation or infection poisoning, at this time the effective circulation of blood redistribution, seen in the blood pressure drop too fast, excessive, or infected with toxic shock.
4. The increase in renal vascular resistance after major surgery and anesthesia; hepatorenal syndrome; prostaglandin secretion such as aspirin, indomethacin and ibuprofen caused by indapamide from prostaglandin inhibitor.
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