Proteinuria is a typical symptom of kidney disease, but the leakage of urine protein does not reflect the severity of kidney disease. The leakage of proteinuria is less than that of renal pathological changes, and a large number of proteinuria can not explain the serious pathological damage of nephropathy. Such as small change, nephritis and mild mesangial proliferative nephritis, kidney lesions are mild, but the daily urine protein can reach several grams or even more than a dozen grams. In general, proteinuria is pided into selective proteinuria and non selective proteinuria. Selective proteinuria refers to the protein electrophoresis characterized by smaller molecular weight proteins, such as albumin, alpha 1 globulin, transferrin and gamma globulin. Relatively large molecular weight proteins, such as alpha 2 globulin, fibrinogen, beta lipoprotein, and so on.
In minimalchange nephropathy, mild mesangial proliferative glomerulonephritis, membranous nephropathy and early lesions in membranous proliferative glomerulonephritis and focal segmental sclerosis nephritis patients showed selective proteinuria, showed little network (glomerular filtration membrane) damage lighter. Non selective proteinuria refers to the fact that protein electrophoresis is characterized by the simultaneous occurrence of large molecules and small molecules of proteins. This indicates that small mesh (glomerular filtration membrane) is more serious.
The number of protein lost, and the severity of the disease is not proportional to. In patients with mild glomerular lesions, urinary protein is not necessarily small, such as minimal change, nephritis and mild mesangial proliferative nephritis, kidney lesions are mild, but the daily amount of urine protein can reach several grams or even more than a dozen grams. In contrast, some focal segmental sclerosing glomerulonephritis and crescentic glomerulonephritis have severe pathological lesions, but daily proteinuria may be only a few grams. Therefore, the quality of treatment depends mainly on the type of kidney pathology, damage and renal function. In addition, it is necessary to see whether the patient can cooperate with the doctor, whether or not to pay attention to prevent the recurrence of incentives (such as colds, fatigue, diarrhea, etc.), whether or not to adhere to the treatment, whether to avoid the use of nephrotoxic drugs.
In summary, proteinuria is a relatively easy to cure disease, because of its many pathogenic factors, so there are many treatment methods. According to my years of working experience, I suggest serious patients use nephrotoxic drugs. The light conditions patient, I recommend using a high quality low protein diet. As long as the above points can be very good treatment of the disease.
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