How is kidney stone formed?

How is kidney stone formed?

The incidence of kidney stones is very high, and very harmful to human health. But many patients may not be aware of the disease. Here's a look

How is kidney stone formed?

Kidney stones are due to some physiological abnormalities in the body caused by the increase in the concentration of crystalline substances in the urine or solubility is reduced, over saturated state

Crystallization and combined with the organic matrix to form nuclei, then the crystals in the kidney of local growth and aggregation of a disease and ultimately the formation of stones. Kidney stones in

There are many factors in the process of formation, the main reasons can be shown as follows:

1, the matrix and the matrix of the core of the matrix: the average matrix accounted for 2.5% of the weight of the stones, belonging to the matrix stones accounted for 65%. Matrix components including proteins,

Carbohydrates and a small amount of inorganic matter, which may be derived from tubular cells, plasma mucins, antigen antibody complexes, or bacteria. Kidney stones

The formation of the matrix shaped ball, the surface folds can adsorb crystalline substance, concentrated and formed outer matrix membrane, crystalline substance again calm, long

For a long time, it will form a laminated stone.

2, the formation of renal calcification plaque: Randall found in patients with kidney stones, kidney stones are formed in the small area of the renal papilla papillary calcification

With the loss of the mucosal surface of the plaque, the plaque is exposed to the urine of the calyx, which continues to grow and is discharged into the renal pelvis or renal pelvis.

In Carr, the plaque was 5 to 6 times larger than that of renal tubular cells, but not in the small lumen of the kidney

Renal papillary region. When lymphatic inflammation or obstruction, plaque can be broken into the kidney, continue to grow and form stones.

3, the formation of supersaturated state: urine crystals, such as calcium and phosphorus ions or cystine, uric acid, magnesium ammonium phosphate and apatite and other substances increased, more than

The solubility of urine, kidney stones is how to form a supersaturated state, after the formation of crystal stones.

4, urinary stone formation inhibitor reduced: kidney stones is how to form a normal urine contains a variety of organic and inorganic substances, can increase the difficulty of urine

Solubility of solute, which can inhibit the formation of stone. Organic matter, such as sulfur in urine, can reduce the calcium oxalate

The solubility of calcium carbonate and calcium oxalate can be inhibited by inorganic substances such as pyrophosphate, which can increase the solubility of calcium oxalate and calcium phosphate

That can combine with calcium citrate and calcium salt deposition inhibition. If these substances decrease or lack, it is conducive to the formation of stones. For recurrent stones, if can fill

Lack of inhibitors, will be able to play a role in preventing recurrence of stones.



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