Etiology of Henoch Schonlein purpura nephritis in children

Etiology of Henoch Schonlein purpura nephritis in children

Children with Henoch Schonlein purpura nephritis in recent years showed a relative increase in the trend is quietly attacking the communication of children due to certain factors caused by systemic vascular inflammatory skin lesions

Is a red rash which called kidney damage is called purpura purpura nephritis.

Nephritis etiology

Nephritis etiology

Allergic purpura (Henoch-Schonlein purpura, HSP) is a kind of allergic reaction that is related to the autoimmune injury of the blood vessel

Of disease, clinical syndrome HSP patients with skin purpura, arthritis and hemorrhagic gastroenteritis glomerulonephritis as the main characteristics of the half appeared

Renal damage, this time called Henoch Schonlein purpura nephritis (anaphy Lactoid purpura nephritis). The basic lesion is IgA deposition in glomerular mesangial area

Mesangial cell proliferation with or without crescent formation. Renal damage occurred more than 3 months after the onset of skin purpura (95%)

Now before the skin purpura, as well as in the skin after 1 years of purpura, but in the next 6 months after the occurrence of renal damage should not generally be regarded as purpura nephritis.

In 1802, Heberden first reported a case of cutaneous purpura associated with gross hematuria, Schö in the year of 1837; nlein was a more detailed description of

The performance of the joint, Heberden reported in 1868, 2355 cases of skin purpura with gastrointestinal symptoms according to Beijing Children's Hospital (~ 1983) HSP data

Analysis, winter and spring for the disease season. Henoch Schonlein purpura nephritis occurs in school-age children more than women, children are the most common secondary glomerular disease

Disease.

Henoch Schonlein purpura nephritis is a leukocytoclastic vasculitis is the main immune complex disease caused by IgA immune complex deposition, the etiology is still unfinished

All clear, may be related to the following factors: infection, vaccination, insect bites, cold stimulation of drug allergy and food allergy etc. Although these factors are likely to be

Induced allergic purpura nephritis clinical reesmbling, but still difficult to clear the allergen desensitization treatment efficacy is not satisfactory.

 

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