Poly-cystic kidney disease is a hereditary kidney disease that causes irreversible loss of renal function, and autosomal dominant poly-cystic kidney disease is the most common in chronic kidney failure. With the progress of medicine and the emergence of new treatment methods, how has treatment of poly-cystic kidney disease progressed in the past decades?
Control high blood pressure
Angiotensin receptor blockers, especially angiotensin-converting enzyme inhibitors, are the drugs of first choice for the treatment of polycystic kidney disease-related hypertension. In the early stages of renal impairment, good blood pressure control (96 / 60-110 / 75mmHg) is beneficial to delay the damage of renal function and reduce the mortality rate of cardiovascular diseases.
Treatment of hyperlipidemia
Chronic kidney disease such as PDK is considered as one of the risk factors of coronary heart disease. Studies have shown that statins can improve renal blood flow and protect the renal vascular endothelial cells in order to protect renal function. However, statins remain difficult to delay the progress of patients with polycystic kidney disease into the uremic stage.
Vasopressin receptor antagonists
In vitro studies have shown that reducing the level of intracellular cyclic adenosine monophosphate is conducive to reducing cystic neoplasm in the course of polycystic kidney disease. Studies have shown that vasopressin receptor antagonists can inhibit the volume enlargement of polycystic kidney disease, slow down the decline of renal function, delay the emergence of clinical progress, and then delay the progression of polycystic kidney disease.
Increase fluid intake
By increasing the liquid intake and thus reduce the plasma levels of vasopressin, can achieve the purpose of inhibiting cyst formation. Liquid intake of more than 3 liters daily can increase urine output, as well as reduce the osmotic pressure of urine and blood levels of antidiuretic hormone, and can reduce the formation of urinary stones in patients. However, excessive drinking levels may increase heart burden and promote impairment of renal function in some patients.
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