How does polycystic kidney disease happen? Polycystic kidney disease is a common hereditary kidney disease, so the main causes of polycystic kidney disease are genetic factors. Moreover, the disease is dominant in adulthood and is recessive in infancy. The kidneys in patients with renal cysts are often significant, 2-3 times larger than normal, and the color can be dark red, dark brown or brownish yellow because of bleeding or infection. In addition, the cysts can be small or can be big, small to large 0.1cm may not, then there is no limit section of kidney showed honeycomb block, can communicate with each other but not between the cyst, renal pelvis and renal cyst connected by compression of the fibrosis changes, the cyst fluid is pale yellow or bloody, sac wall is composed of cuboidal epithelial cells. The cystic wall below many arteries, due to increased pressure, infection and other reasons, even rupture caused by hematuria.
There are 3 kinds of polycystic kidney disease gene mutation caused by adult polycystic kidney, according to experts will be found in order, they were named as PKD1, PKD2, PKD3, PKD1 and PKD2 genes have been cloned, PKD1 is the main cause of adult polycystic kidney disease, accounting for about 85%, and the most serious symptoms. PKD1 gene is located in 16p13.3-p13.12, 52kb in length, including 46 exons, exon 1~34 of multicopy region, exon 35~46 was a single copy region, respectively 70% and 30% gene regions, a glycoprotein protein composed of 4302 amino acids, called polycystic egg white -1. The content of C, G gene sequence was 62.5%, multi - purine in exon 22 and intron 21 were rich in 2.5kb and 0.5kb for a long period of the polypyrimidine tract, easy to form the three strands of DNA helical structure, in addition to the first exon of 1-33 containing Alu repeats ranging from the number (2-11) also, there are 6 homologous sequences in other parts of the chromosome. Tongshantang experts said, according to Statistics estimates, more than 80% of the PKD1 gene mutation occurred in a gene; the gene mutation is not much, most are concentrated in the 3 'end of specific fragment (repeat region), the remaining mutations may be found throughout the main gene, deletion, frameshift, no mutation and missense meaning which led polycystic kidney disease.
The above is the polycystic kidney disease, hope that through tongshantang expert commentary, making of polycystic kidney disease can have a deeper understanding. Understanding polycystic kidney disease, thus far away from polycystic kidney disease.
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