Polycystic kidney disease is a more common kidney disease, according to statistics from patients with polycystic kidney disease gradually increased, then why is suffering from polycystic kidney disease, polycystic kidney is how the formation of, you should not know, let's let We up to explore what is the cause of polycystic kidney disease.
What is the cause of polycystic kidney disease?
The abnormal gene of the patient is located on the short arm of chromosome 16, called the ADPKD1 gene, and the gene product is unclear. Many of the coding genes in this region have been elucidated and cloned, and in the near future ADPKD1 can be identified for polycystic kidney disease.
In addition, some patients with abnormal gene located in chromosome 4 short arm, called ADPKD2 gene, the coding product is not clear. The age of the two groups in the onset, high blood pressure and renal failure were different. The exact cause of this disease is not clear. Although most of the symptoms after the adult, but in the fetus began to form. Cysts originated in the renal tubules, the liquid properties with the origin of different parts, originated in the proximal tubules, cyst fluid components such as Na +, K +, CI-, H +, creatinine, urea and plasma similar to the origin; Cysteine Na +, K + concentration is low, CI-, H +, creatinine, urea and other high concentrations. Abnormal proliferation of glomerular epithelial cells in patients with polycystic kidney disease is one of the significant characteristics of ADPKD, in a mature incomplete or re-development state, highly suggestive of the development of mature bacterial regulation obstacles, so that cells in a Immature state, which shows strong proliferation.
This cell transport abnormality is another significant feature of ADPKD, which is manifested as a subcellular association of Na + -K + -ATPase closely related to cell transport, distribution and changes in the expression of activity; cell signaling abnormalities and changes in ion transport channels. Abnormal proliferation of extracellular matrix is the third significant feature of ADPKD. At present, many studies have shown that these abnormalities are involved in cell growth-related activity factors. But the key part of the unusual links and the way is not yet clear. In short, due to genetic defects caused by cell growth changes and interstitial abnormalities, one of the important pathogenesis of this disease.
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