Well known, drug is not food, is not to avoid health care products, will have certain side effects, the range of their side effects damage is closely related to the drug itself characteristics. Particularly large number of chemical synthetic drug are widely used, resulting in a series of confusing and difficult to control the damage, called drug-induced disease.
Kidney damage is the current focus on clinical questions, to kidney disease patients because application nephrotoxicity drugs and makes a sharp deterioration in renal function. Due to kidney blood supply greatly, the purpose is as a filter to the metabolic waste in the body, the amount of blood make up about a quarter of the whole body, is bigger than any organ, on the one hand, full of kidney function, on the other hand, a large number of drugs through the kidneys. Drugs in the kidney, there are many drugs subject to kidney metabolism and excretion, and because of renal tubular reabsorption and shedding effects of certain drugs, such drug concentration is high in the malpighian tube, have a greater chance of kidney damage, and renal glomerular capillaries within large filtration area, drugs and the contact area of the corresponding also is very big. A variety of factors, show the kidney as one of drug metabolism organ, and easy for drug.
Drug damage to the kidney method has two kinds, one is direct damage, such as renal toxicity drugs can damage to the renal tubules directly, related to the concentration of the drug, as the crystallization of sulfa drugs can cause renal obstruction, and so on mechanical damage. The other is a collateral damage, the damage many ways; Are mainly allergic damage, immune complex lesions, and blood flow dynamics and rheology change damage, electrolyte disorder caused by damage, the damage to the kidney drug can directly lead to the renal tubular necrosis; Permeability kidney disease; Nephritis or other glomerular changes; Obstructive nephropathy, etc.
At the same time, the existing decreased renal function, such as the elderly, slow kidney disease patients, more is led to further deterioration of renal function. Cause damage to the kidney drug mainly include: pain relievers, vitamin a, d, penicillin, gentamicin, kanamycin, sulphonamide, amphotericin b, anti-tb drugs such as antibiotics, ethyl ether, cyclopropane, morphine, carbon monoxide, such as medicine, osmotic diuresis medicine, mercury diuretics, benzene thiazole class diuretics most applications such as improper diuretic, all kinds of contrast agents, antineoplastic drugs, table mould amine etc. Should pay attention to is that some drugs are often kidney patients commonly used medicines, such as a diuretic, etc., thus should be under the guidance of doctors use, avoid by all means, bought since from taking kidney patients the best drugs under the guidance of specialized subject doctor.
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