The cause of glomerulonephritis, Beijing Tongshantang kidney disease hospital for your summary
Referred to as "chronic nephritis, chronic glomerulonephritis proteinuria, hematuria, hypertension, oedema as basic clinical manifestations, have disease way is different, may increase, pathological changes slowly, can have different degrees of renal impairment, will eventually develop into a group of glomerular disease, chronic renal failure. Due to this disease of pathological type and different period, the main clinical manifestations can vary, disease present persified performance.
Nephritis whether genetic nephritis can genetic depends on what kind of nephritis. Some nephritis is hereditary, especially the hereditary nephritis, it can be inherited by parents to their children, is an autosomal dominant genetic disease, to pass on to future generations. Nephritis have disease symptoms usually not obvious, when children often only urine check had mild proteinuria and hematuria, and often after an intense workout or upper respiratory tract infection after aggravating. General proteinuria with age, and gradually increase, the inpidual cases may have severe proteinuria. Rare increased blood pressure, often to the late only moderately elevated blood pressure. Disease continued to progress slowly, more male how serious illness, often died of chronic renal failure in the prime of life, female the illness is lighter, can have a normal life. Streptococcus suis infection (30%) :
A family of group B is the most main cause glomerulonephritis hemolytic streptococcus bacteria, a family of group B hemolytic streptococcus infection after tonsillitis, scarlet fever, hatched from bacteria antigens and antibodies (immunoglobulins) in the human body, form the antigen antibody immune complex, deposition in the glomerular basement membrane, can cause a series of inflammatory reaction. Virus infection (20%) :
, measles virus, influenza virus infection such as chickenpox virus, mumps virus, adenovirus, although in the incidence of acute glomerulonephritis is low, its mechanism is not yet clear, but if the history of virus infection without clinical symptoms of bacterial infection, urine change light, not typical, nephritis syndrome after a virus infection should be considered in glomerulonephritis. Other (15%) :
Syphilis, brucellosis, typhoid fever, typhus, infection, fungal infection after and so on, also can cause acute glomerulonephritis. Non-infectious diseases, such as foreign protein intake, drugs, tumor, systemic diseases such as lupus erythematosus, etc., can also lead to acute glomerulonephritis.
The etiology and pathogenesis of chronic glomerulonephritis and only a minority of chronic glomerulonephritis is caused by the urgent friends to development of nephritis. But most of the etiology is not clear, the pathogenesis and acute nephritis, is an autoimmune reaction process. But why is unclear, the mechanism of chronic process may be associated with the defects exist certain immune function. Immune function defect can decrease the body's ability to fight infection, microbial attack repeatedly; The body does not produce enough antibodies, to remove pathogenic substance (antigen), the antigen can persist in the body, and formation of immune complex deposition in renal tissue, chronic inflammatory process.
In addition, non immune-mediated kidney damage in the occurrence and development of chronic nephritis may also play an important role, such as woods nephron compensatory elevated serum perfusion pressure, increased glomerular capillary loops transmembrane pressure and the filtration pressure, all can lead to glomerular sclerosis. Disease in the process of high blood pressure, exist for a long time, can lead to renal artery stenosis, occlusion, accelerated glomerular sclerosis.
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