Mention "gout", a lot of people think that is a big meal after the big flesh, the night big toe swollen, pain drills, it is difficult to sleep; but there is such a motto - "There is no trouble in the world is a Dayton barbecue can not solve, if not resolved, then eat a meal, "gout does not hurt, and beer baked again. Therefore, gout is also a very easy to relapse of the disease. But you know, gout, pain is not just your joints, and your kidneys
Chronic gouty nephropathy mechanism: hyperuricemia caused by renal overload excretion of uric acid: the kidneys are excreted uric acid main organs, excessive excretion of uric acid uric acid is easy to cause uric acid crystals deposited in the kidney tissue, the deposition site is mainly between the kidney Quality tissue, leading to interstitial nephritis, can also block the kidney collection tube. Although only 1/3 of the gout patients with clinical manifestations of kidney damage, but its severity is much greater than arthritis. And the degree of renal damage and arthritis is not necessarily parallel.
High uric acid: renal tubular lumen and urinary uric acid concentration can cause significant damage to the kidneys, the degree of damage even more than the increase in serum uric acid concentration is more serious. Combined with the complications caused by renal damage: the so-called "gouty kidney disease" mostly non-simple hyperuricemia caused by, and on the basis of this combination of obesity, hypertension, hyperlipidemia, diabetes, Arteriosclerosis, coronary heart disease, cerebrovascular disease, kidney stones and urinary tract infections and other factors involved. These combined diseases or complications can aggravate kidney damage and complicate the condition. For example, gout patients with hypertension than the control group more than twice as high, but whether the early manifestations of renal damage, or high blood pressure caused by kidney damage, and sometimes difficult to understand.
Clinical manifestations of gouty kidney disease: gouty kidney disease progress is extremely slow, many patients can be a long course of several decades without clinical symptoms. Once the symptoms, can be expressed as the following seven aspects:
Low back pain and edema: Early patients may have mild back pain, either unilateral or bilateral. 40% to 45% of patients may have mild edema. Hypertension: 40% to 45% of patients with moderate hypertension, blood pressure fluctuations in 20 ~ 24,12 ~ 16kPa (150 ~ 180,90 ~ 120mmHg), with the general antihypertensive drugs can be controlled. Mild proteinuria: about 85% of gout patients before the occurrence of renal damage, often have a few years of intermittent or persistent mild proteinuria, urinary protein does not exceed (++), rarely a lot of proteinuria. Urine pH is acidic and hematuria: gout urine pH mostly persistent acid, to promote the formation of stones. About 54% of patients may develop gross hematuria. Pyelonitis symptoms: gout patients often secondary infection, urinary frequency, urgency, dysuria, bacteriuria and fever symptoms. Renal failure: especially young gouty kidney disease, increased in the kidney after 5 to 10 years, advanced glomerular function is also impaired, there decreased creatinine clearance, urea nitrogen rise, the patient was uremic clinical manifestations, about 10% In uremia. Such as early diagnosis and appropriate treatment, kidney disease can reduce or stop the development, this is different from other irreversible kidney disease. Extraperitoneal lesions: including joint disease, pain stone formation and other manifestations, such as may be associated with coronary atherosclerotic heart disease, cerebrovascular accident and primary hypertension, but also associated with diabetes and so on.
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